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Table 1 Advantages and disadvantages of tools that might be used to screen patients with T2D for UDCI

From: Unrecognised cardiovascular disease in type 2 diabetes: is it time to act earlier?

Tool

Advantages

Disadvantages

Questionnaires

Can be carried out by a variety of people with limited affect to its validity and reliability

Results can be quickly and easily quantified

Can be analysed more ‘scientifically’ and objectively than other forms of research

Can be used to compare and contrast data and to measure change

Patients may provide the answers that they think are expected

Lacks validity

It is difficult to assess how much thought a patient has given to each question

The interpretation of each question may differ

Digital data gathering (e.g. wearable personal health tracker)

Provide continuous, objective, remote monitoring

Patients can monitor and self-manage behaviours

A significant volume of data can be captured

Data collected may promote beneficial lifestyle changes

Accuracy may be affected by factors such as individual gait characteristics, body morphology, and where and how a device is worn on the body

Patients may place greater faith in the accuracy of the device than is warranted

Sensitive data may be captured with resultant privacy issues

Stress test or 6-minute walking test

Practical and simple requiring no specialised equipment

Evaluates the global and integrated responses of all the systems involved during exercise

Useful for measuring the response to medical interventions

Findings are reproducible

Additional cardiopulmonary exercise testing may be required

Adherence to strict protocols is required to ensure validity of data collected

Biomarkers

Free from recall bias

Can provide sensitive and specific early detection of disease

Usually require a sample of body fluid to be taken

Inter-individual variability may be a concern

Specialised laboratory analysis may be required

Reproducibility could be a concern

May not be cost-effective