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Table 3 Association of per 1.0 SD increase in serum OCN, FGF23 and NGAL levels with visceral obesity (VFA ≥ 80 cm2)

From: Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

Variable Individual models Combined model, adjusted
Unadjusted Adjusted
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Total (n = 1179)
OCN 0.647 (0.570–0.734) < 0.001 0.727 (0.621–0.852) < 0.001 0.743 (0.632–0.872) < 0.001
FGF23 1.367 (1.212–1.541) < 0.001 1.326 (1.143–1.538) < 0.001 1.335 (1.149–1.552) < 0.001
NGAL 1.471 (1.299–1.667) < 0.001 1.291 (1.112–1.500) 0.001 1.291 (1.110–1.503) 0.001
Normal glucose tolerance (n = 633)
OCN 0.659 (0.551–0.788) < 0.001 0.745 (0.589–0.942) 0.014 0.747 (0.589–0.947) 0.016
FGF23 1.290 (1.103–1.507) 0.001 1.263 (1.033–1.545) 0.023 1.269 (1.036–1.555) 0.022
NGAL 1.487 (1.245–1.776) < 0.001 1.253 (1.011–1.553) 0.040 1.257 (1.013–1.559) 0.037
Hyperglycaemia (n = 546)
OCN 0.654 (0.545–0.785) < 0.001 0.724 (0.579–0.905) 0.005 0.760 (0.605–0.955) 0.019
FGF23 1.545 (1.271–1.879) < 0.001 1.383 (1.095–1.746) 0.006 1.383 (1.093–1.750) 0.007
NGAL 1.443 (1.205–1.728) < 0.001 1.321 (1.065–1.639) 0.011 1.304 (1.045–1.628) 0.019
  1. Adjustment was for age, gender, menopausal status (in women), smoking, SBP, DBP, HbA1c, HOMA-IR, TG, HDL-C, LDL-C, CRP, Ca, and eGFR. For the individual models, each bone-derived secretory factor was analyzed separately; for the combined model, serum OCN, FGF23, and NGAL levels were included in the model simultaneously
  2. SD, standard deviation; OCN, osteocalcin; FGF23, fibroblast growth factor 23; NGAL, neutrophil gelatinase-associated lipocalin; VFA, visceral fat area; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated haemoglobin A1c; HOMA-IR, homeostasis model assessment-insulin resistance index; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; Ca, calcium; eGFR, estimated glomerular filtration rate