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Table 3 Association of per 1.0 SD increase in serum OCN, FGF23 and NGAL levels with visceral obesity (VFA ≥ 80 cm2)

From: Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

Variable

Individual models

Combined model, adjusted

Unadjusted

Adjusted

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Total (n = 1179)

OCN

0.647 (0.570–0.734)

< 0.001

0.727 (0.621–0.852)

< 0.001

0.743 (0.632–0.872)

< 0.001

FGF23

1.367 (1.212–1.541)

< 0.001

1.326 (1.143–1.538)

< 0.001

1.335 (1.149–1.552)

< 0.001

NGAL

1.471 (1.299–1.667)

< 0.001

1.291 (1.112–1.500)

0.001

1.291 (1.110–1.503)

0.001

Normal glucose tolerance (n = 633)

OCN

0.659 (0.551–0.788)

< 0.001

0.745 (0.589–0.942)

0.014

0.747 (0.589–0.947)

0.016

FGF23

1.290 (1.103–1.507)

0.001

1.263 (1.033–1.545)

0.023

1.269 (1.036–1.555)

0.022

NGAL

1.487 (1.245–1.776)

< 0.001

1.253 (1.011–1.553)

0.040

1.257 (1.013–1.559)

0.037

Hyperglycaemia (n = 546)

OCN

0.654 (0.545–0.785)

< 0.001

0.724 (0.579–0.905)

0.005

0.760 (0.605–0.955)

0.019

FGF23

1.545 (1.271–1.879)

< 0.001

1.383 (1.095–1.746)

0.006

1.383 (1.093–1.750)

0.007

NGAL

1.443 (1.205–1.728)

< 0.001

1.321 (1.065–1.639)

0.011

1.304 (1.045–1.628)

0.019

  1. Adjustment was for age, gender, menopausal status (in women), smoking, SBP, DBP, HbA1c, HOMA-IR, TG, HDL-C, LDL-C, CRP, Ca, and eGFR. For the individual models, each bone-derived secretory factor was analyzed separately; for the combined model, serum OCN, FGF23, and NGAL levels were included in the model simultaneously
  2. SD, standard deviation; OCN, osteocalcin; FGF23, fibroblast growth factor 23; NGAL, neutrophil gelatinase-associated lipocalin; VFA, visceral fat area; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated haemoglobin A1c; HOMA-IR, homeostasis model assessment-insulin resistance index; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; Ca, calcium; eGFR, estimated glomerular filtration rate