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Table 4 Unmachted univariable and multivariable hazard ratios for the association of diabetics with the primary prognostic endpoint of long-term all-cause mortality at 2 years in pre-specified sub-groups

From: Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias

 

n (%)

Univariable

Multivariablea

HR

95% CI

p value

HR

95% CI

p value

Total cohort

2422 (100)

1.513

1.322–1.731

0.001

1.209

1.010–1.447

0.039

Females

684 (28)

1.472

1.144–1.895

0.003

0.881

0.606–1.280

0.506

Males

1738 (72)

1.528

1.303–1.792

0.001

1.328

1.080–1.632

0.007

Age < 70 years

1365 (56)

1.564

1.258–1.945

0.001

1.189

0.950–1.488

0.131

Age > 70 years

1057 (44)

1.245

1.047–1.481

0.013

1.369

1.019–1.840

0.037

Ventricular tachycardia

1364 (56)

2.030

1.658–2.486

0.001

1.351

1.041–1.754

0.024

Ventricular fibrillation

1058 (44)

1.222

1.018–1.466

0.032

1.039

0.803–1.344

0.771

Chronic kidney disease

1194 (49)

1.267

1.084–1.481

0.003

1.206

0.984–1.478

0.071

No chronic kidney disease

1228 (51)

1.564

1.170–2.089

0.002

1.206

0.819–1.776

0.342

Acute myocardial infarction

691 (29)

1.291

1.020–1.634

0.033

1.569

1.144–2.150

0.005

ST segment elevation myocardial infarction

237 (10)

1.155

0.723–1.846

0.546

1.441

0.711–2.922

0.311

Non segment elevation myocardial infarction

454 (19)

1.309

0.995–1.721

0.054

1.692

1.180–2.425

0.004

Coronary artery disease, overall

1490 (62)

2.113

1.687–2.646

0.001

1.327

1.078–1.634

0.008

Coronary multivessel disease

721 (30)

1.221

0.953–1.563

0.114

1.516

1.110–2.070

0.009

No coronary artery disease

932 (39)

1.306

1.103–1.547

0.002

0.943

0.653–1.362

0.753

LVEF ≥ 55%

532 (22)

2.494

1.725–3.606

0.001

1.248

0.835–1.866

0.280

LVEF < 55%

1247 (51)

1.600

1.320–1.941

0.001

1.192

0.975–1.457

0.086

Implantable cardioverter defibrillator

860 (36)

2.046

1.447–2.893

0.001

1.859

1.272–2.715

0.001

 Primary prevention

397 (16)

2.736

1.688–4.436

0.001

1.902

1.116–3.242

0.018

 Secondary prevention

463 (20)

1.577

0.957–2.600

0.074

1.651

0.940–2.900

0.081

No implantable cardioverter defibrillator

1562 (64)

1.466

1.266–1.698

0.001

1.086

0.885–1.332

0.430

  1. CI confidence interval, HR hazard ratio, LVEF left ventricular ejection faction
  2. Level of significance p < 0.05; statistical trend p < 0.1
  3. aMultivariable models were adjusted for age, gender, chronic kidney disease, ventricular tachyarrhythmias, LV dysfunction, CPR, AMI and presence of an activated ICD (overall)