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Table 4 Unmachted univariable and multivariable hazard ratios for the association of diabetics with the primary prognostic endpoint of long-term all-cause mortality at 2 years in pre-specified sub-groups

From: Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias

  n (%) Univariable Multivariablea
HR 95% CI p value HR 95% CI p value
Total cohort 2422 (100) 1.513 1.322–1.731 0.001 1.209 1.010–1.447 0.039
Females 684 (28) 1.472 1.144–1.895 0.003 0.881 0.606–1.280 0.506
Males 1738 (72) 1.528 1.303–1.792 0.001 1.328 1.080–1.632 0.007
Age < 70 years 1365 (56) 1.564 1.258–1.945 0.001 1.189 0.950–1.488 0.131
Age > 70 years 1057 (44) 1.245 1.047–1.481 0.013 1.369 1.019–1.840 0.037
Ventricular tachycardia 1364 (56) 2.030 1.658–2.486 0.001 1.351 1.041–1.754 0.024
Ventricular fibrillation 1058 (44) 1.222 1.018–1.466 0.032 1.039 0.803–1.344 0.771
Chronic kidney disease 1194 (49) 1.267 1.084–1.481 0.003 1.206 0.984–1.478 0.071
No chronic kidney disease 1228 (51) 1.564 1.170–2.089 0.002 1.206 0.819–1.776 0.342
Acute myocardial infarction 691 (29) 1.291 1.020–1.634 0.033 1.569 1.144–2.150 0.005
ST segment elevation myocardial infarction 237 (10) 1.155 0.723–1.846 0.546 1.441 0.711–2.922 0.311
Non segment elevation myocardial infarction 454 (19) 1.309 0.995–1.721 0.054 1.692 1.180–2.425 0.004
Coronary artery disease, overall 1490 (62) 2.113 1.687–2.646 0.001 1.327 1.078–1.634 0.008
Coronary multivessel disease 721 (30) 1.221 0.953–1.563 0.114 1.516 1.110–2.070 0.009
No coronary artery disease 932 (39) 1.306 1.103–1.547 0.002 0.943 0.653–1.362 0.753
LVEF ≥ 55% 532 (22) 2.494 1.725–3.606 0.001 1.248 0.835–1.866 0.280
LVEF < 55% 1247 (51) 1.600 1.320–1.941 0.001 1.192 0.975–1.457 0.086
Implantable cardioverter defibrillator 860 (36) 2.046 1.447–2.893 0.001 1.859 1.272–2.715 0.001
 Primary prevention 397 (16) 2.736 1.688–4.436 0.001 1.902 1.116–3.242 0.018
 Secondary prevention 463 (20) 1.577 0.957–2.600 0.074 1.651 0.940–2.900 0.081
No implantable cardioverter defibrillator 1562 (64) 1.466 1.266–1.698 0.001 1.086 0.885–1.332 0.430
  1. CI confidence interval, HR hazard ratio, LVEF left ventricular ejection faction
  2. Level of significance p < 0.05; statistical trend p < 0.1
  3. aMultivariable models were adjusted for age, gender, chronic kidney disease, ventricular tachyarrhythmias, LV dysfunction, CPR, AMI and presence of an activated ICD (overall)