Fig. 9
From: MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin
Schematic representation of the association among miR-21, GSN, and diastolic dysfunction in diabetic cardiomyopathy. In db/db mice, decreased miR-21 resulted in GSN overexpression, which increased ROS, decreased NO production, and enhanced cardiac hypertrophy, which finally impaired cardiac diastolic dysfunction