Glycemic variability determined with a continuous glucose monitoring system can predict prognosis after acute coronary syndrome

Hironori Takahashi; Noriaki Iwahashi; Jin Kirigaya; Shunsuke Kataoka; Yugo Minamimoto; Masaomi Gohbara; Takeru Abe; Kozo Okada; Yasushi Matsuzawa; Masaaki Konishi; Nobuhiko Maejima; Kiyoshi Hibi; Masami Kosuge; Toshiaki Ebina; Kouichi Tamura; Kazuo Kimura

doi:10.1186/s12933-018-0761-5

Table 3 Univariate logistic regression analysis for the prediction of MACCE in ACS patients

From: Glycemic variability determined with a continuous glucose monitoring system can predict prognosis after acute coronary syndrome

Variables	OR	95% CI	p-value
Age, per 1 year	1.007	0.985–1.031	0.511
Male	0.990	0.489–2.005	0.978
Body mass index, per 1 kg/m²	0.943	0.872–1.015	1.060
STE-ACS	0.831	0.474–1.456	0.559
Killip class > 1	1.028	0.520–2.037	0.935
Culprit LAD	0.982	0.579–1.666	0.947
Culprit LCx	0.488	0.169–1.411	0.177
Cilprit RCA	1.300	0.757–2.234	0.341
Multivessel disease	0.411	0.240–0.704	0.001
GRACE score > 140	1.283	0.756–2.178	0.355
Hypertension	0.838	0.492–1.429	0.516
Hypercholesterolemia	1.053	0.614–1.804	0.852
Systolic blood pressure on admission, per 1 mmHg	0.995	0.988–1.002	0.214
Heart rate on admission, per 1 bpm	1.003	0.990–1.017	0.638
Cre on admission, per 1 mg/dl	1.598	0.909–2.914	0.098
eGFR on admission, per 1%	0.996	0.982–1.008	0.522
Peak level of CPK, per 1 IU/l	1.000	0.999–1.000	0.534
BNP during stable phase, per 1 pg/ml	1.001	1.000–1.003	0.013
hs-CRP during stable phase > 0.1355 mg/dl	2.278	1.325–3.915	0.002
LDL cholesterol, per 1 mg/dl	1.000	0.993–1.007	0.994
HDL cholesterol, per 1 mg/dl	0.972	0.946–0.996	0.030
Triglycerides, per 1 mg/dl	0.999	0.997–1.001	0.571
ACE-I or ARB use at discharge	0.737	0.396–1.374	0.336
β-blocker use at discharge	1.127	0.642–1.979	0.676
Statin use at discharge	0.596	0.188–1.888	0.374
Diabetes mellitus	1.251	0.726–2.158	0.420
Impaired glucose tolerance	1.218	0.719–2.063	0.463
Normal glucose tolerance	0.510	0.242–1.074	0.072
Glucose on admission > 180 mg/dl	2.238	1.286–3.893	0.004
Hemoglobin A1c level, %	1.267	1.030–1.546	0.021
High MAGE	2.347	1.378–3.998	0.001
Ave, mg/dl	1.001	0.998–1.013	0.155
SD	1.016	0.994–1.038	0.141
CV	1.020	0.982–1.058	0.293

LAD left anterior descending coronary artery, LCx left circumflex coronary artery, RCA, right coronary artery, OR odds ratio, 95% CI 95% confidence interval. Other abbreviations as in Tables 1, 2

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