Age group (reference: 50–54 years old)
|
55–59 years old
|
1.08 (0.86, 1.36)
|
0.513
|
1.01 (0.85, 1.21)
|
0.883
|
1.33 (0.84, 2.11)
|
0.230
|
60–64 years old
|
1.24 (1.00, 1.54)
|
0.049*
|
1.12 (0.95, 1.33)
|
0.168
|
1.72 (1.11, 2.66)
|
0.014*
|
65–69 years old
|
1.35 (1.10, 1.67)
|
0.005*
|
1.20 (1.01, 1.41)
|
0.033*
|
2.15 (1.41, 3.28)
|
< 0.001*
|
70–74 years old
|
1.52 (1.24, 1.88)
|
< 0.001*
|
1.30 (1.11, 1.54)
|
0.001*
|
2.67 (1.76, 4.06)
|
< 0.001*
|
75–79 years old
|
1.72 (1.40, 2.12)
|
< 0.001*
|
1.43 (1.21, 1.68)
|
< 0.001*
|
3.13 (2.06, 4.75)
|
< 0.001*
|
80–84 years old
|
2.20 (1.79, 2.70)
|
< 0.001*
|
1.82 (1.55, 2.14)
|
< 0.001*
|
4.60 (3.04, 6.97)
|
< 0.001*
|
85 and above
|
2.23 (1.79, 2.77)
|
< 0.001*
|
1.81 (1.52, 2.15)
|
< 0.001*
|
4.82 (3.14, 7.39)
|
< 0.001*
|
Race (reference: Caucasian)
|
African American
| | | | |
0.81 (0.70, 0.93)
|
0.003*
|
Asian
| | | | |
0.58 (0.37, 0.92)
|
0.021*
|
Other/unknown
| | | | |
1.04 (0.93, 1.17)
|
0.474
|
Ethnicity (reference: non-Hispanic)
|
Hispanic
|
0.98 (0.82, 1.17)
|
0.830
|
0.92 (0.79, 1.08)
|
0.315
|
0.69 (0.51, 0.93)
|
0.016*
|
Unknown
|
1.16 (1.10, 1.24)
|
< 0.001*
|
1.14 (1.09, 1.20)
|
< 0.001*
|
1.14 (1.03, 1.27)
|
0.013*
|
End of baseline period prior to 2011a
|
1.43 (1.34, 1.53)
|
< 0.001*
|
1.39 (1.32, 1.48)
|
< 0.001*
|
1.83 (1.67, 2.01)
|
< 0.001*
|
Geographic region (reference: South)
|
Midwest
| | | | |
0.83 (0.75, 0.91)
|
< 0.001*
|
Northeast
| | | | |
0.73 (0.63, 0.83)
|
< 0.001*
|
West
| | | | |
0.84 (0.73, 0.97)
|
0.014*
|
Other/unknown
| | | | |
1.07 (0.85, 1.33)
|
0.570
|
Insurance type (reference: health maintenance organization [HMO])
|
Point-of-service (POS)
| | |
1.11 (0.97, 1.27)
|
0.142
|
0.79 (0.60, 1.05)
|
0.105
|
Preferred provider organization (PPO)
| | |
1.21 (1.08, 1.34)
|
< 0.001*
|
0.84 (0.69, 1.03)
|
0.092
|
Exclusive provider organization (EPO)
| | |
1.08 (0.86, 1.36)
|
0.483
|
0.58 (0.34, 0.98)
|
0.043*
|
Indemnity (IND)
| | |
1.29 (1.07, 1.55)
|
0.007*
|
1.23 (0.91, 1.66)
|
0.183
|
Other
| | |
1.01 (0.96, 1.07)
|
0.631
|
0.89 (0.81, 0.98)
|
0.018*
|
Payer type
|
Commercial
|
0.81 (0.75, 0.89)
|
< 0.001*
|
0.77 (0.68, 0.87)
|
< 0.001*
|
0.84 (0.67, 1.06)
|
0.135
|
Prior CVD diagnoses (ref: no diagnosis)
|
Myocardial infarction
|
1.24 (1.16, 1.33)
|
< 0.001*
|
1.13 (1.07, 1.20)
|
< 0.001*
| | |
Stroke
|
1.34 (1.26, 1.43)
|
< 0.001*
|
1.13 (1.06, 1.19)
|
< 0.001*
| | |
Congestive heart failure
|
1.39 (1.30, 1.49)
|
< 0.001*
|
1.91 (1.80, 2.03)
|
< 0.001*
|
1.97 (1.78, 2.18)
|
< 0.001*
|
Time from last observed CVD diagnosis to end of baseline period, months (reference: less than 1 month)
|
1–3 months
|
0.80 (0.73, 0.87)
|
< 0.001*
|
0.76 (0.70, 0.82)
|
< 0.001*
|
0.83 (0.74, 0.93)
|
0.002*
|
3–6 months
|
0.66 (0.60, 0.73)
|
< 0.001*
|
0.62 (0.57, 0.67)
|
< 0.001*
|
0.63 (0.56, 0.72)
|
< 0.001*
|
6–12 months
|
0.58 (0.53, 0.63)
|
< 0.001*
|
0.52 (0.48, 0.56)
|
< 0.001*
|
0.51 (0.45, 0.58)
|
< 0.001*
|
12 months and above
|
0.56 (0.51, 0.61)
|
< 0.001*
|
0.48 (0.45, 0.52)
|
< 0.001*
|
0.48 (0.42, 0.54)
|
< 0.001*
|
Other CVD-related conditions (i.e., Conditions used to define CVD-related death)
|
1.10 (1.00, 1.20)
|
0.043*
|
1.18 (1.09, 1.27)
|
< 0.001*
| | |
At least 1 diabetes-related hospitalization
|
1.30 (1.23, 1.39)
|
< 0.001*
|
1.27 (1.20, 1.33)
|
< 0.001*
|
1.36 (1.25, 1.49)
|
< 0.001*
|
Adapted diabetes complications severity index
|
1.10 (1.08, 1.11)
|
< 0.001*
|
1.09 (1.07, 1.11)
|
< 0.001*
|
1.11 (1.09, 1.13)
|
< 0.001*
|
Recorded diagnoses (ref: no diagnosis)
|
Mental disorders
| | | | |
1.14 (1.05, 1.24)
|
0.002*
|
Chronic pulmonary disease
|
1.18 (1.11, 1.25)
|
< 0.001*
|
1.27 (1.21, 1.34)
|
< 0.001*
|
1.28 (1.18, 1.40)
|
< 0.001*
|
Obesity
|
0.81 (0.74, 0.89)
|
< 0.001*
| | |
0.78 (0.68, 0.88)
|
< 0.001*
|
Cancer
| | | | |
1.16 (1.05, 1.29)
|
0.005*
|
Peripheral vascular disorders
| | |
1.07 (1.01, 1.13)
|
0.017*
| | |
Fluid and electrolyte disorders
|
1.16 (1.09, 1.24)
|
< 0.001*
|
1.14 (1.08, 1.21)
|
< 0.001*
|
1.15 (1.05, 1.26)
|
0.002*
|
Deficiency anemia
|
1.19 (1.10, 1.28)
|
< 0.001*
|
1.15 (1.08, 1.23)
|
< 0.001*
|
1.22 (1.10, 1.35)
|
< 0.001*
|
Erectile dysfunction, organic origin
| | | | |
0.60 (0.43, 0.84)
|
0.003*
|
Coagulopathy
| | |
1.14 (1.05, 1.24)
|
0.003*
|
1.17 (1.02, 1.33)
|
0.024*
|
Pulmonary circulation disorders
| | |
1.21 (1.12, 1.30)
|
< 0.001*
|
1.33 (1.18, 1.49)
|
< 0.001*
|
Time interval (reference: 0–6 months)
|
6–12 months
|
0.82 (0.76, 0.89)
|
< 0.001*
|
0.78 (0.73, 0.83)
|
< 0.001*
|
0.89 (0.79, 0.99)
|
0.030*
|
12–18 months
|
0.77 (0.70, 0.84)
|
< 0.001*
|
0.74 (0.69, 0.80)
|
< 0.001*
|
0.81 (0.72, 0.93)
|
0.002*
|
18–24 months
|
0.80 (0.72, 0.89)
|
< 0.001*
|
0.70 (0.64, 0.77)
|
< 0.001*
|
0.82 (0.71, 0.95)
|
0.009*
|
24–30 months
|
0.71 (0.62, 0.80)
|
< 0.001*
|
0.58 (0.52, 0.66)
|
< 0.001*
|
0.78 (0.65, 0.92)
|
0.004*
|
30–36 months
|
0.67 (0.58, 0.78)
|
< 0.001*
|
0.57 (0.50, 0.66)
|
< 0.001*
|
0.79 (0.65, 0.96)
|
0.019*
|
36–42 months
|
0.71 (0.59, 0.84)
|
< 0.001*
|
0.63 (0.54, 0.74)
|
< 0.001*
|
0.73 (0.58, 0.93)
|
0.009*
|
42–48 months
|
0.77 (0.63, 0.93)
|
0.007*
|
0.70 (0.59, 0.83)
|
< 0.001*
|
0.77 (0.59, 1.00)
|
0.052
|
48–54 months
|
0.61 (0.47, 0.78)
|
< 0.001*
|
0.50 (0.39, 0.63)
|
< 0.001*
|
0.66 (0.48, 0.90)
|
0.010*
|
54–60 months
|
0.69 (0.53, 0.91)
|
0.007*
|
0.63 (0.49, 0.81)
|
< 0.001*
|
0.75 (0.53, 1.05)
|
0.097
|
Over 60 months
|
0.56 (0.46, 0.69)
|
< 0.001*
|
0.50 (0.41, 0.61)
|
< 0.001*
|
0.51 (0.38, 0.67)
|
< 0.001*
|