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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

Fig. 5

Schematic description of the cellular signaling involved in the development of cardiomyopathy in diabetes and proposed mechanism for the effect of CR on the diabetic heart. The energetic dysfunction in diabetes manifested by increased FFA in the heart together with elevation in local and systematic production of Angiotensin leads to mitochondrial dysfunction, oxidative stress and inflammation. In the diabetic heart PARP-1 and ERK are elevated, promoting the development of cardiac hypertrophy. CR elevates adiponectin, pAMPKand SIRT-1 levels. This leads to the activation of both PGC-1α and improved mitochondrial function, alleviate the oxidative stress and reduce inflammation by CR ameliorating cardiomyopathy

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