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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

Fig. 3

CR alleviates oxidative stress through the activation of PGC-1α. MDA levels in the serum were measured using TBARS kit, n = 4 in each group (a). PGC-1α protein levels in the cytoplasmic (cyto) and nuclear (nuc) fractions (b) as well as mRNA expression levels (c) were measured in the cardiac tissue (c). Cardiac SOD2 protein levels (d). n = 4 in each group, *p < 0.05 vs. WT, #p < 0.05 vs. db/db &p < 0.05 vs. db/db + AT. Values represent mean ± SD

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