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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

Fig. 1

CR attenuates fibrosis and inflammation in diabetic mice. Representive pictures of leukocytes infiltration and fibrotic tissue (arrows) that were observed in the heart of AT treated mice as seen by Masson’s trichrome (AF) and Hematoxylin &Eosin (GI) staining. The percentage of fibrotic area was calculated (M). *p < 0.05 vs. WT, ^p < 0.05 vs. WT + AT, &p < 0.05 vs. db/db + AT. n = 3 in each group. Values represent mean ± SD. CR reduced the cardiac mRNA levels of TGFβ (N), ANP (O), TNFα (P), BNP (Q), MMP2 (R). *p < 0.05 vs. WT, #p < 0.05 vs. db/db, &p < 0.05 vs. db/db + AT. n = 5 in each group. Values represent mean ± SD

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