DIABHYCAR | p | SURDIAGENE | p | |||
---|---|---|---|---|---|---|
No events | Incident cases | No events | Incident cases | |||
N | 2521 | 577 | 894 | 513 | ||
Sex: male (%) | 72 | 79 | 0.0003 | 55 | 63 | 0.006 |
Age (years) | 65 ± 8 | 68 ± 8 | < 0.0001 | 63 ± 11 | 69 ± 10 | < 0.0001 |
BMI (kg/m2) | 29.5 ± 4.6 | 28.8 ± 4.5 | 0.0006 | 31.7 ± 6.5 | 30.8 ± 5.8 | 0.01 |
Duration of diabetes (years) | 10 ± 8 | 11 ± 8 | 0.0003 | 13 ± 10 | 17 ± 10 | < 0.0001 |
HbA1c (%) | 7.8 ± 1.7 | 8.1 ± 1.9 | 0.006 | 7.7 ± 1.6 | 7.9 ± 1.5 | 0.03 |
HbA1c (mmol/mol) | 62 ± 19 | 65 ± 20 | 0.007 | 61 ± 17 | 63 ± 16 | 0.02 |
Systolic blood pressure (mmHg) | 145 ± 14 | 147 ± 14 | 0.002 | 131 ± 17 | 135 ± 19 | < 0.0001 |
Diastolic blood pressure (mmHg) | 82 ± 8 | 82 ± 8 | 0.87 | 73 ± 11 | 72 ± 12 | 0.40 |
Arterial Hypertension (%) | 55 | 63 | 0.0003 | 79 | 91 | < 0.0001 |
UAC (mg/l)* | 72 (126) | 107 (254) | <0.0001 | 19 (60) | 48 (257) | < 0.0001 |
UAC | ||||||
Normoalbuminuria (%) | 0 | 0 | 51.8 | 35.7 | ||
Microalbuminuria (%) | 78.6 | 67.4 | < 0.0001 | 36.7 | 36.4 | < 0.0001 |
Macroalbuminuria (%) | 21.4 | 32.6 | 11.5 | 27.9 | ||
Creatinine (µmol/l) | 88 ± 20 | 95 ± 20 | < 0.0001 | 90 ± 59 | 122 ± 95 | < 0.0001 |
eGFR (ml/min/1.73 m2) | 78 ± 20 | 73 ± 19 | < 0.0001 | 78 ± 22 | 62 ± 27 | < 0.0001 |
KDIGO | ||||||
G1 (%) | 26.0 | 17.8 | < 0.0001 | 36.7 | 17.0 | < 0.0001 |
G2 (%) | 56.2 | 55.5 | 43.6 | 38.4 | ||
G3A (%) | 15.8 | 21.8 | 10.7 | 19.5 | ||
G3B (%) | 2.0 | 4.9 | 6.2 | 10.5 | ||
G4 (%) | 0 | 0 | 1.6 | 10.5 | ||
G5 (%) | 0 | 0 | 1.2 | 4.1 | ||
Total cholesterol (mmol/l) | 5.76 ± 1.06 | 5.95 ± 1.09 | <0.0001 | 4.75 ± 1.13 | 4.83 ± 1.22 | 0.30 |
HDL cholesterol (mmol/l) | 1.33 ± 0.36 | 1.26 ± 0.32 | < 0.0001 | 1.20 ± 0.41 | 1.18 ± 0.41 | 0.34 |
Triglycerides (mmol/l) | 2.19 ± 1.44 | 2.32 ± 1.29 | 0.003 | 1.90 ± 1.30 | 1.97 ± 1.69 | 0.81 |
Previous myocardial infarction (%) | 4 | 12 | < 0.0001 | 9 | 27 | <0.0001 |
Active tobacco smoking (%) | 14 | 15 | 0.55 | 12.0 | 8.1 | 0.02 |
Copeptin (pmol/l)* | 7.1 (6.6) | 7.9 (7.4) | 0.0001 | 6.2 (7.0) | 8.4 (11.4) | < 0.0001 |