|
N
|
2521
|
577
| |
894
|
513
| |
|
Sex: male (%)
|
72
|
79
|
0.0003
|
55
|
63
|
0.006
|
|
Age (years)
|
65 ± 8
|
68 ± 8
|
< 0.0001
|
63 ± 11
|
69 ± 10
|
< 0.0001
|
|
BMI (kg/m2)
|
29.5 ± 4.6
|
28.8 ± 4.5
|
0.0006
|
31.7 ± 6.5
|
30.8 ± 5.8
|
0.01
|
|
Duration of diabetes (years)
|
10 ± 8
|
11 ± 8
|
0.0003
|
13 ± 10
|
17 ± 10
|
< 0.0001
|
|
HbA1c (%)
|
7.8 ± 1.7
|
8.1 ± 1.9
|
0.006
|
7.7 ± 1.6
|
7.9 ± 1.5
|
0.03
|
|
HbA1c (mmol/mol)
|
62 ± 19
|
65 ± 20
|
0.007
|
61 ± 17
|
63 ± 16
|
0.02
|
|
Systolic blood pressure (mmHg)
|
145 ± 14
|
147 ± 14
|
0.002
|
131 ± 17
|
135 ± 19
|
< 0.0001
|
|
Diastolic blood pressure (mmHg)
|
82 ± 8
|
82 ± 8
|
0.87
|
73 ± 11
|
72 ± 12
|
0.40
|
|
Arterial Hypertension (%)
|
55
|
63
|
0.0003
|
79
|
91
|
< 0.0001
|
|
UAC (mg/l)*
|
72 (126)
|
107 (254)
|
<0.0001
|
19 (60)
|
48 (257)
|
< 0.0001
|
|
UAC
|
|
Normoalbuminuria (%)
|
0
|
0
| |
51.8
|
35.7
| |
|
Microalbuminuria (%)
|
78.6
|
67.4
|
< 0.0001
|
36.7
|
36.4
|
< 0.0001
|
|
Macroalbuminuria (%)
|
21.4
|
32.6
| |
11.5
|
27.9
| |
|
Creatinine (µmol/l)
|
88 ± 20
|
95 ± 20
|
< 0.0001
|
90 ± 59
|
122 ± 95
|
< 0.0001
|
|
eGFR (ml/min/1.73 m2)
|
78 ± 20
|
73 ± 19
|
< 0.0001
|
78 ± 22
|
62 ± 27
|
< 0.0001
|
|
KDIGO
|
|
G1 (%)
|
26.0
|
17.8
|
< 0.0001
|
36.7
|
17.0
|
< 0.0001
|
|
G2 (%)
|
56.2
|
55.5
|
43.6
|
38.4
|
|
G3A (%)
|
15.8
|
21.8
|
10.7
|
19.5
|
|
G3B (%)
|
2.0
|
4.9
|
6.2
|
10.5
|
|
G4 (%)
|
0
|
0
|
1.6
|
10.5
|
|
G5 (%)
|
0
|
0
|
1.2
|
4.1
|
|
Total cholesterol (mmol/l)
|
5.76 ± 1.06
|
5.95 ± 1.09
|
<0.0001
|
4.75 ± 1.13
|
4.83 ± 1.22
|
0.30
|
|
HDL cholesterol (mmol/l)
|
1.33 ± 0.36
|
1.26 ± 0.32
|
< 0.0001
|
1.20 ± 0.41
|
1.18 ± 0.41
|
0.34
|
|
Triglycerides (mmol/l)
|
2.19 ± 1.44
|
2.32 ± 1.29
|
0.003
|
1.90 ± 1.30
|
1.97 ± 1.69
|
0.81
|
|
Previous myocardial infarction (%)
|
4
|
12
|
< 0.0001
|
9
|
27
|
<0.0001
|
|
Active tobacco smoking (%)
|
14
|
15
|
0.55
|
12.0
|
8.1
|
0.02
|
|
Copeptin (pmol/l)*
|
7.1 (6.6)
|
7.9 (7.4)
|
0.0001
|
6.2 (7.0)
|
8.4 (11.4)
|
< 0.0001
|
