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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury

Fig. 6

Glycemic control by the SGLT2 inhibitor empagliflozin (EMPA) decreases macro- and micro-vascular stiffening, renal resistivity index, and kidney injury. Hyperglycemia (1) in type 2 diabetes causes aortic stiffness (2), which is associated with increased renal arterial stiffness (3), albuminuria (4) and tubulointerstitial fibrosis (5). Hyperglycemia suppresses the anti-fibrotic factor RECK in proximal tubular cells (6). Importantly, inhibition of SGLT2 by EMPA (7 and 8) enhances glycosuria (9), inhibits aortic and renal vascular stiffening, reverses RECK suppression, reduces kidney fibrosis and albuminuria, and blunts progression of kidney disease (10)

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