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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice

Fig. 6

Atherosclerotic lesion characteristics in APOE(−/−) mice fed with HFD and treated with canagliflozin (Cana-group) or vehicle (control-group). a Selected 4 μm image sections from the aortic root, immunostained for smooth muscle cells (α-Actin), MCP-1, MMP-9 and MMP-2, macrophages (CD68), and TIMP-1/TIMP-2. b Immunostaining differences between groups. Positive cell proportion stained with each antibody was scored from 0 to 4 and staining intensity from 0 to 3 with 0 representing no visual staining and 4 representing intense staining (> 75% of area). Immunoreactivity was scored on a 0–7 scale [extend of staining (0–4) plus intensity of staining (0–3)]. There was a significant difference in MCP-1 expression between Cana-group and control-group (P = 0.048). A-actin and CD68 expression were numerically higher in the Control-group (P = 0.1). Bar graphs show mean ± SD and *P < 0.05. (Original magnification ×200; scale bar, 150 μm)

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