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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice

Fig. 5

a VCAM-1, MCP-1 and TIMP-1 mRNA expression from thoracic aorta of mice treated with canagliflozin (10 mg/kg/day—5 weeks) and control-group (vehicle—5 weeks). VCAM-1 mRNA expression was significantly decreased in Cana-group as well as MCP-1, while TIMP-1 mRNA expression was increased. b TIMP-1/MMP-2 ratio mRNA was also increased in Cana-group (compared to control-group) approaching the borderline of significance (P = 0.07). Data are presented as mean (**P < 0.01)

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