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Table 2 Experimentally validated miRNA:mRNA targets in HUVECs

From: Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

Gene

Binding location

Regulation

Pathways/functions

CSTB

chr21:43774214–43774239

Down

Immune system (reactome)

EIF5

chr14:103342859–103342887; chr14:103336755–103336777

Down

RNA transport (KEGG)

Gene expression (reactome)

IQGAP1

chr15:90492649–90492672; chr15:90482260–90482275

Down

Proteoglycans in cancer (KEGG)

Adherence junction (KEGG)

Cell–cell communication (reactome)

KLF7

chr2:207088518–207088545

Down

Adipogenesis

MAPRE1

chr20:32833787–32833796

Down

Organelle (KEGG)

MARCKSL1

chr1:32334564–32334592

Down

Fc-gamma R-mediated

MCAM

chr11:119310410–119310423

Down

Adhesion

MDN1

chr6:89718909–89718936

Down

Ribosome biogenesis (KEGG)

PWP1

chr12:107688737–107688759

Down

RHOB

chr2:20449368–20449389

Down

Axon guidance (KEGG)

SNAP29

chr22:20890084–20890104

Down

Membrane trafficking (reactome)

SNN*

chr16:11678992–11679013

Down

TNFRSF10B

chr8:23020409–23020435

Down

p53 signalling pathway (KEGG)

ZBTB38

chr3:141444493–141444514

Down

ZFYVE20 (also RBSN)

chr3:15096210–15096236

Down

Endocytosis (KEGG)

  1. For * SNN gene, no data are reported, but SNN interacts with YWHAZ and YWHAB genes of both “Hippo signalling pathway” (not reported in table) and “Cell cycle” of the related predicted KEGG pathways