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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

Fig. 5

HFD-fed β GC-A KO mice exhibit accelerated glucose intolerance. Fasting blood glucose concentrations (a) and blood glucose concentrations during oral glucose tolerance test (oGTT, b) were determined in 16-h-fasted β GC-A KO and control littermates after 8 weeks of ND or HFD (n = 13 mice per genotype and condition). c Area under the curve (AUC) during oral glucose tolerance tests (oGTT) performed in 16-h-fasted β GC-A KO and control littermates after 8 weeks (n = 13), 12 weeks (n = 6–8) or 18 weeks (n = 6–8) of ND or HFD. d Blood glucose concentration and area under the curve (AUC) during insulin tolerance test (ITT) performed in 4-h-fasted β GC-A KO and control mice after 8 weeks of HFD (n = 10 per genotype). e Fasting (basal) plasma insulin levels and glucose-stimulated insulin secretion (GSIS) were determined in 16-h-fasted β GC-A KO and control littermates on ND (left panel) or HFD (right panel) (n = 10 per genotype). *P < 0.05 vs ND or basal; #P < 0.05 vs control mice

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