Skip to main content
Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

Fig. 3

The insulinotropic effects of exogenous BNP are abolished in β GC-A KO mice. Fasted and oral glucose-stimulated plasma insulin levels (GSIS, top) as well as oral glucose tolerance (oGTT, bottom) were determined in 16-h-fasted control (a) and β GC-A KO littermates (b) after 7 days of subcutaneous vehicle or BNP infusions via osmotic minipumps (n = 6 mice per genotype). *P < 0.05 and **P < 0.01 vs basal; #P < 0.05 vs vehicle treatment (GSIS) or baseline (oGTT before BNP)

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840