Table 7 Synergistic effect of NOS3 T, CETP B1 and ANGPTL8 T alleles on the risk of T2DM and CVD
NOS3 T | CETP B1 | ANGPTL8 T | Total T2DM patients % OR (95% CI) p-value | T2DM without CVDa % OR (95% CI) p-value | T2DM + CVD % OR (95% CI) p-value | Control % |
|---|---|---|---|---|---|---|
− | − | − | 41.7 | 44.5 | 50 | 64.3 |
− | + | + | 8.3 | 5.5 | 5.5 | 28.5 |
|  |  |  | 0.4 (0.17–1.10) p = 0.07 | 0.69 (0.08–5.46) p = 0.7 | 0.19 (0.04–0.88) p = 0.3 |  |
+ | + | − | 39 | 39 | 33.3 | 7.2 |
|  |  |  | 8.36 (3.35–20.87) p < 0.0001** | 7.87 (1.54–40.09) p = 0.006** | 6.33 (2.29–17.46) p = 0.0002** |  |
+ | − | + | 2.7 | 0 | 5.7 | 0 |
|  |  |  | 1.88 (0.11–31.09) p = 0.9 | 4.25 (0.25–71.6) p = 0.35 | 5.9 (0.51–68.29) p = 0.17 |  |
+ | + | + | 8.3 | 11 | 5.5 | 0 |
|  |  |  | 13.22 (1.56–111.7) p = 0.004** | 13.8 (1.63–116.5) p = 0.008** | 8.86 (0.87–89.54) p = 0.03** |  |