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Table 7 Synergistic effect of NOS3 T, CETP B1 and ANGPTL8 T alleles on the risk of T2DM and CVD

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

NOS3 T CETP B1 ANGPTL8 T Total T2DM patients % OR (95% CI) p-value T2DM without CVDa % OR (95% CI) p-value T2DM + CVD % OR (95% CI) p-value Control %
41.7 44.5 50 64.3
+ + 8.3 5.5 5.5 28.5
    0.4 (0.17–1.10) p = 0.07 0.69 (0.08–5.46) p = 0.7 0.19 (0.04–0.88) p = 0.3  
+ + 39 39 33.3 7.2
    8.36 (3.35–20.87) p < 0.0001** 7.87 (1.54–40.09) p = 0.006** 6.33 (2.29–17.46) p = 0.0002**  
+ + 2.7 0 5.7 0
    1.88 (0.11–31.09) p = 0.9 4.25 (0.25–71.6) p = 0.35 5.9 (0.51–68.29) p = 0.17  
+ + + 8.3 11 5.5 0
    13.22 (1.56–111.7) p = 0.004** 13.8 (1.63–116.5) p = 0.008** 8.86 (0.87–89.54) p = 0.03**  
  1. Data shown as frequency (%)
  2. **Significant p
  3. aT2DM patients vs. T2DM + CVD