Table 7 Synergistic effect of NOS3 T, CETP B1 and ANGPTL8 T alleles on the risk of T2DM and CVD
| NOS3 T | CETP B1 | ANGPTL8 T |
Total T2DM patients % OR (95% CI) p-value |
T2DM without CVDa % OR (95% CI) p-value |
T2DM + CVD % OR (95% CI) p-value |
Control % |
|---|---|---|---|---|---|---|
| − | − | − | 41.7 | 44.5 | 50 | 64.3 |
| − | + | + | 8.3 | 5.5 | 5.5 | 28.5 |
|
0.4 (0.17–1.10) p = 0.07 |
0.69 (0.08–5.46) p = 0.7 |
0.19 (0.04–0.88) p = 0.3 | ||||
| + | + | − | 39 | 39 | 33.3 | 7.2 |
|
8.36 (3.35–20.87) p < 0.0001** |
7.87 (1.54–40.09) p = 0.006** |
6.33 (2.29–17.46) p = 0.0002** | ||||
| + | − | + | 2.7 | 0 | 5.7 | 0 |
|
1.88 (0.11–31.09) p = 0.9 |
4.25 (0.25–71.6) p = 0.35 |
5.9 (0.51–68.29) p = 0.17 | ||||
| + | + | + | 8.3 | 11 | 5.5 | 0 |
|
13.22 (1.56–111.7) p = 0.004** |
13.8 (1.63–116.5) p = 0.008** |
8.86 (0.87–89.54) p = 0.03** |