Skip to main content

Table 7 Synergistic effect of NOS3 T, CETP B1 and ANGPTL8 T alleles on the risk of T2DM and CVD

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

NOS3 T CETP B1 ANGPTL8 T Total T2DM patients
%
OR (95% CI)
p-value
T2DM without CVDa
%
OR (95% CI)
p-value
T2DM + CVD
%
OR (95% CI)
p-value
Control
%
41.7 44.5 50 64.3
+ + 8.3 5.5 5.5 28.5
    0.4 (0.17–1.10)
p = 0.07
0.69 (0.08–5.46)
p = 0.7
0.19 (0.04–0.88)
p = 0.3
 
+ + 39 39 33.3 7.2
    8.36 (3.35–20.87)
p < 0.0001**
7.87 (1.54–40.09)
p = 0.006**
6.33 (2.29–17.46)
p = 0.0002**
 
+ + 2.7 0 5.7 0
    1.88 (0.11–31.09)
p = 0.9
4.25 (0.25–71.6)
p = 0.35
5.9 (0.51–68.29)
p = 0.17
 
+ + + 8.3 11 5.5 0
    13.22 (1.56–111.7)
p = 0.004**
13.8 (1.63–116.5)
p = 0.008**
8.86 (0.87–89.54)
p = 0.03**
 
  1. Data shown as frequency (%)
  2. **Significant p
  3. aT2DM patients vs. T2DM + CVD