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Table 7 Synergistic effect of NOS3 T, CETP B1 and ANGPTL8 T alleles on the risk of T2DM and CVD

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

NOS3 T

CETP B1

ANGPTL8 T

Total T2DM patients

%

OR (95% CI)

p-value

T2DM without CVDa

%

OR (95% CI)

p-value

T2DM + CVD

%

OR (95% CI)

p-value

Control

%

41.7

44.5

50

64.3

+

+

8.3

5.5

5.5

28.5

   

0.4 (0.17–1.10)

p = 0.07

0.69 (0.08–5.46)

p = 0.7

0.19 (0.04–0.88)

p = 0.3

 

+

+

39

39

33.3

7.2

   

8.36 (3.35–20.87)

p < 0.0001**

7.87 (1.54–40.09)

p = 0.006**

6.33 (2.29–17.46)

p = 0.0002**

 

+

+

2.7

0

5.7

0

   

1.88 (0.11–31.09)

p = 0.9

4.25 (0.25–71.6)

p = 0.35

5.9 (0.51–68.29)

p = 0.17

 

+

+

+

8.3

11

5.5

0

   

13.22 (1.56–111.7)

p = 0.004**

13.8 (1.63–116.5)

p = 0.008**

8.86 (0.87–89.54)

p = 0.03**

 
  1. Data shown as frequency (%)
  2. **Significant p
  3. aT2DM patients vs. T2DM + CVD