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Table 6 Associations of studied polymorphisms with the risk of CVD in T2DM

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

SNP Genotype distributiona Additive model Dominant model Recessive model
T2DM (n = 68) T2DM + CVD (n = 68) OR (95% CI) p OR (95% CI) p OR (95% CI) p
ANGPTL8 rs2278426
C/C 53 (78) 62 (91.2) 1.0 (reference)     
C/T 12 (17.6) 5 (7.4) 2.8 (0.92–8.48) 0.15 0.34 (0.12–0.94) 0.05 0.32 (0.03–3.1) 0.6
T/T 3 (4.4) 1 (1.4) 3.50 (0.35–34.74)   (C/C vs. C/T + T/T) (C/C + C/T vs. T/T)
Allele C 118 (86.7) 129 (96.3) 2.8 (1.13–6.97) 0.03*   
Allele T 18 (13.3) 7 (3.7)     
CETP rs708272
GG 30 (44) 32 (47.1) 1.0   
GA 32 (47) 26 (38.2) 0.7(0.37–1.56) 0.4 0.88 (0.45–1.74) 0.8 1.78 (0.60–5.21) 0.4
AA 6 (9) 10 (14.7) 0.6 (0.20–1.97)   (G/G/vs. G/A + A/A) (G/G + G/A vs. A/A)
Allele G 92 (67.6) 90 (66.2) 1.06 (0.64–1.77) 0.89   
Allele A 44 (32.4) 46 (33.8)     
NOS3 rs1799983
GG 44 (67.4) 41 (60.3) 1.0 (reference)   
GT 20 (29.4) 24 (35.3) 0.7 (0.37–1.61) 0.7 0.82 (0.41–1.66) 0.7 1.35 (0.29–6.29) 1.0
TT 4 (5.9) 3 (4.4) 1.37 (0.29–6.39)   (G/G vs. G/T + T/T) (G/G +G/T vs. T/T)
Allele G 108 (79.4) 106 (78) 0.91 (0.51–1.63) 0.88   
Allele T 28 (20.6) 30 (22)     
  1. * significant p
  2. Alleles frequency calculated in 2N
  3. aData shown as number of subjects (%)