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Table 6 Associations of studied polymorphisms with the risk of CVD in T2DM
| SNP | Genotype distributiona | Additive model | Dominant model | Recessive model | ||||
|---|---|---|---|---|---|---|---|---|
| T2DM (n = 68) | T2DM + CVD (n = 68) | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| ANGPTL8 rs2278426 | ||||||||
| C/C | 53 (78) | 62 (91.2) | 1.0 (reference) | – | ||||
| C/T | 12 (17.6) | 5 (7.4) | 2.8 (0.92–8.48) | 0.15 | 0.34 (0.12–0.94) | 0.05 | 0.32 (0.03–3.1) | 0.6 |
| T/T | 3 (4.4) | 1 (1.4) | 3.50 (0.35–34.74) | (C/C vs. C/T + T/T) | (C/C + C/T vs. T/T) | |||
| †Allele C | 118 (86.7) | 129 (96.3) | 2.8 (1.13–6.97) | 0.03* | ||||
| Allele T | 18 (13.3) | 7 (3.7) | ||||||
| CETP rs708272 | ||||||||
| GG | 30 (44) | 32 (47.1) | 1.0 | – | ||||
| GA | 32 (47) | 26 (38.2) | 0.7(0.37–1.56) | 0.4 | 0.88 (0.45–1.74) | 0.8 | 1.78 (0.60–5.21) | 0.4 |
| AA | 6 (9) | 10 (14.7) | 0.6 (0.20–1.97) | (G/G/vs. G/A + A/A) | (G/G + G/A vs. A/A) | |||
| Allele G | 92 (67.6) | 90 (66.2) | 1.06 (0.64–1.77) | 0.89 | ||||
| Allele A | 44 (32.4) | 46 (33.8) | ||||||
| NOS3 rs1799983 | ||||||||
| GG | 44 (67.4) | 41 (60.3) | 1.0 (reference) | – | ||||
| GT | 20 (29.4) | 24 (35.3) | 0.7 (0.37–1.61) | 0.7 | 0.82 (0.41–1.66) | 0.7 | 1.35 (0.29–6.29) | 1.0 |
| TT | 4 (5.9) | 3 (4.4) | 1.37 (0.29–6.39) | (G/G vs. G/T + T/T) | (G/G +G/T vs. T/T) | |||
| Allele G | 108 (79.4) | 106 (78) | 0.91 (0.51–1.63) | 0.88 | ||||
| Allele T | 28 (20.6) | 30 (22) | ||||||
