Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

Table 6 Associations of studied polymorphisms with the risk of CVD in T2DM

SNP	Genotype distribution^a		Additive model		Dominant model		Recessive model
SNP	T2DM (n = 68)	T2DM + CVD (n = 68)	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
ANGPTL8 rs2278426
C/C	53 (78)	62 (91.2)	1.0 (reference)	–
C/T	12 (17.6)	5 (7.4)	2.8 (0.92–8.48)	0.15	0.34 (0.12–0.94)	0.05	0.32 (0.03–3.1)	0.6
T/T	3 (4.4)	1 (1.4)	3.50 (0.35–34.74)		(C/C vs. C/T + T/T)		(C/C + C/T vs. T/T)
^†Allele C	118 (86.7)	129 (96.3)	2.8 (1.13–6.97)	0.03*
Allele T	18 (13.3)	7 (3.7)
CETP rs708272
GG	30 (44)	32 (47.1)	1.0	–
GA	32 (47)	26 (38.2)	0.7(0.37–1.56)	0.4	0.88 (0.45–1.74)	0.8	1.78 (0.60–5.21)	0.4
AA	6 (9)	10 (14.7)	0.6 (0.20–1.97)		(G/G/vs. G/A + A/A)		(G/G + G/A vs. A/A)
Allele G	92 (67.6)	90 (66.2)	1.06 (0.64–1.77)	0.89
Allele A	44 (32.4)	46 (33.8)
NOS3 rs1799983
GG	44 (67.4)	41 (60.3)	1.0 (reference)	–
GT	20 (29.4)	24 (35.3)	0.7 (0.37–1.61)	0.7	0.82 (0.41–1.66)	0.7	1.35 (0.29–6.29)	1.0
TT	4 (5.9)	3 (4.4)	1.37 (0.29–6.39)		(G/G vs. G/T + T/T)		(G/G +G/T vs. T/T)
Allele G	108 (79.4)	106 (78)	0.91 (0.51–1.63)	0.88
Allele T	28 (20.6)	30 (22)

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