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Table 5 Association of studied polymorphisms with the risk of CVD compared to control under different genetic models

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

SNP Genotype distributiona Additive model Dominant model Recessive model
Controls N = 136 Patients N = 68 OR (95% CI) p OR (95% CI) p OR (95% CI) p
ANGPTL8 rs2278426
C/C 118 (87) 62 (91) 1.0     
C/T 16 (12) 5 (8) 0.70 (0.26–1.91) 0.79 1.35 (0.53–3.40) 0.3 1.01 (0.09–11.39) 0.7
T/T 2 (1) 1 (1) 0.95 (0.08–10.70)   (C/C vs. C/T + T/T) (C/C + C/T vs. T/T)
CETP rs708272
GG 44 (32) 32 (47.1) 1.0   
GA 72 (53) 26 (38.2) 0.6 (0.32–1.14) 0.07 1.34 (0.75–2.42) 0.2 0.4 (0.18–1.16) 0.08
AA 20 (15) 10 (14.7) 1.68 (0.63–4.49)   (G/G/vs. G/A + A/A) (G/G + G/A vs. A/A)
NOS3 rs1799983
GG 117 (86) 41 (60.3) 1.0   
GT 16 (11.7) 24 (35.3) 4.09 (1.98–8.47) 0.0001* 0.25 (0.12–0.49) < 0.0001* 2.05 (0.40–10.41) 0.6
TT 3 (2.3) 3 (4.4) 2.73 (0.53–14.08)   (G/G vs. G/T + T/T) (G/G +G/T vs. T/T)
  1. * Significant p
  2. aData shown as number of subjects (frequency)