Table 5 Association of studied polymorphisms with the risk of CVD compared to control under different genetic models
SNP | Genotype distributiona | Additive model | Dominant model | Recessive model | ||||
|---|---|---|---|---|---|---|---|---|
Controls N = 136 | Patients N = 68 | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
ANGPTL8 rs2278426 | ||||||||
C/C | 118 (87) | 62 (91) | 1.0 | – |  |  |  |  |
C/T | 16 (12) | 5 (8) | 0.70 (0.26–1.91) | 0.79 | 1.35 (0.53–3.40) | 0.3 | 1.01 (0.09–11.39) | 0.7 |
T/T | 2 (1) | 1 (1) | 0.95 (0.08–10.70) |  | (C/C vs. C/T + T/T) | (C/C + C/T vs. T/T) | ||
CETP rs708272 | ||||||||
GG | 44 (32) | 32 (47.1) | 1.0 | – |  |  | ||
GA | 72 (53) | 26 (38.2) | 0.6 (0.32–1.14) | 0.07 | 1.34 (0.75–2.42) | 0.2 | 0.4 (0.18–1.16) | 0.08 |
AA | 20 (15) | 10 (14.7) | 1.68 (0.63–4.49) |  | (G/G/vs. G/A + A/A) | (G/G + G/A vs. A/A) | ||
NOS3 rs1799983 | ||||||||
GG | 117 (86) | 41 (60.3) | 1.0 | – |  |  | ||
GT | 16 (11.7) | 24 (35.3) | 4.09 (1.98–8.47) | 0.0001* | 0.25 (0.12–0.49) | < 0.0001* | 2.05 (0.40–10.41) | 0.6 |
TT | 3 (2.3) | 3 (4.4) | 2.73 (0.53–14.08) |  | (G/G vs. G/T + T/T) | (G/G +G/T vs. T/T) | ||