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Table 1 Demographic, clinical and biochemical data of the studied participants

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

Variable Controls (n = 136) T2DM (n = 68) T2DM + CVD (n = 68)
Age (years) 52.3 ± 2.5 51.8 ± 4.3 55.3 ± 5.7
Sex (male/female) 76/60 35/33 42/26
BMI (kg/m2) 26.1 ± 3.8 27.2 ± 2.7* 27.6 ± 2.2**
SBP (mmHg) 112 ± 8.5 125 ± 12 141 ± 20**,†
DBP (mmHg) 74 ± 7.5 87 ± 12 88 ± 10**,†
Hypertension (%) 30 92
Smokers (%) 8 5.8 11.8
Diabetes duration (years) 7.5 ± 4.5 12.5 ± 3.4
FPG (mg/dL) 82 ± 7.5 135 ± 59* 166 ± 61**
HbA1c (%) 5.7 ± 0.5 6.8 ± 2.1* 6.9 ± 1.9**
TG (mg/dL) 127 ± 31 155 ± 70* 161 ± 56**,†
TC (mg/dL) 165 ± 20 178 ± 51* 200 ± 45**,†
LDL-C (mg/dL) 100 ± 22 120 ± 35.5* 126 ± 30**,†
HDL-C (mg/dL) 51.8 ± 7.9 48.5 ± 10.8* 44.1 ± 12.2**,†
  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c hemoglobin A1C, TG triglyceride, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol
  2. * Significant p in comparison between controls and T2DM
  3. ** Significant p in comparison between controls and T2DM + CVD
  4. Significant p in comparison between T2DM and T2DM + CVD