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Table 1 Animal characteristics and laboratory parameters

From: Dual inhibition of sodium–glucose linked cotransporters 1 and 2 exacerbates cardiac dysfunction following experimental myocardial infarction

  sham + vehicle sham + dapa sham + T-1095 MI + vehicle MI + dapa MI + T-1095
N 12 7 6 22 13 15
BW (g) 305.3 ± 3.8 281.3 ± 3.3* 248.3 ± 8.1* 299.9 ± 3.1 282.8 ± 5.0* 263.5 ± 4.2*
LV W/TL (g/mm) 14.8 ± 0.1 13.4 ± 0.1* 12.2 ± 0.3* 15.9 ± 0.2* 15.0 ± 0.2 14.1 ± 0.4
Lung W/TL (g/mm) 27.4 ± 0.5 26.8 ± 0.3 24.7 ± 0.4 43.7 ± 3.9* 40.3 ± 4.4* 54.2 ± 5.0*
UG (mmol/l) 0.34 ± 0.07 316.0 ± 34.3* 256.2 ± 66.6* 0.21 ± 0.03 235.0 ± 10.3* 205.2 ± 21.6*
Fructosamine (μM) 141.8 ± 3.3 126.2 ± 2.4* 129.2 ± 2.8* 121.5 ± 3.3* 122.5 ± 2.0* 130.8 ± 4.4*
ANP: RPL13a mRNA (AU) 1.09 ± 0.23 1.39 ± 0.44 1.52 ± 0.23 13.02 ± 2.33* 7.47 ± 1.15* 9.61 ± 1.07*
  1. BW body weight, SBP systolic blood pressure, LVW left ventricle weight, TL tibia length, Lung W lung weight, BG blood glucose, UG urinary glucose, ANP atrial natriuretic peptide, RPL13a Ribosomal Protein L13a, AU arbitrary units, dapa dapagliflozin
  2. * p < 0.05 vs. sham + vehicle group;  p < 0.05 vs. MI + vehicle group