Table 3 Multivariable Cox analysis for composite endpoints

HbA1c-SD (high, low)

1.485

1.251–1.763

< 0.001

–

–

–

HbA1c-CV (high, low)

–

–

–

1.378

1.160–1.638

< 0.001

E/e′

1.045

1.008–1.084

0.018

1.040

01.003–1.079

0.034

LVEF (≥ 50, 40–49, < 40%)

1.093

0.989–1.208

0.081

1.106

1.001–1.222

0.048

age

1.011

0.999–1.022

0.069

1.010

0.999–1.022

0.073

eGFR

0.995

0.985–1.004

0.262

0.994

0.984–1.003

0.184

Beta-blocker

0.810

0.668–0.982

0.032

0.794

0.655–0.964

0.020

ACEI/ARB

1.029

0.827–1.280

0.799

1.018

0.818–1.266

0.873

BNP (tertile)

1.149

1.035–1.276

0.009

1.136

1.017–1.261

0.017

Ischemic HF

1.097

0.925–1.300

0.288

1.095

0.924–1.298

0.296

NYHA

1.075

0.963–1.201

0.199

1.085

0.971–1.212

0.148

Gender

0.916

0.760–1.103

0.354

0.921

0.764–1.109

0.386

Baseline HbA1c

0.994

0.862–1.146

0.933

0.987

0.856–1.137

0.854

Number of HbA1c measurements

1.010

0.968–1.154

0.646

1.007

0.965–1.051

0.739

HbA1c–mean

0.992

0.864–1.140

0.911

1.066

0.926–1.227

0.372