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Table 2 Multivariable Cox analysis for all-cause mortality

From: Prognostic impact of HbA1c variability on long-term outcomes in patients with heart failure and type 2 diabetes mellitus

 

HR (model 1)

95% confidence interval

P value

HR (model 2)

95% confidence interval

P value

HbA1c-SD (high, low)

1.649

1.288–2.110

< 0.001

–

–

–

HbA1c-CV (high, low)

–

–

–

1.558

1.216–1.997

< 0.001

E/e′

1.069

1.015–1.125

0.011

1.063

1.010–1.119

0.019

LVEF (≥ 50, 40–49, < 40%)

1.159

1.003–1.340

0.045

1.178

1.019–1.362

0.021

Age

1.014

0.997–1.030

0.109

1.014

0.997–1.031

0.104

eGFR

0.990

0.977–1.003

0.142

0.989

0.976–1.003

0.115

ACEI/ARB

0.705

0.526–0.945

0.019

0.701

0.523–0.940

0.018

Beta-blocker

0.738

0.564–0.965

0.026

0.719

0.549–0.941

0.016

BNP (tertiles)

1.335

1.146–1.555

< 0.001

1.317

1.131–1.534

< 0.001

Ischemic HF

1.076

0.846–1.370

0.550

1.067

0.838–1.359

0.598

NYHA

1.103

0.994–1.287

0.217

1.019

0.949–1.296

0.191

Gender

1.098

0.849–1.421

0.475

1.111

0.859–1.438

0.423

Baseline HbA1c

1.045

0.850–1.285

0.674

1.036

0.843–1.274

0.733

Number of HbA1c measurements

1.034

0.974–1.098

0.277

1.030

0.970–1.094

0.332

HbA1c-mean

1.085

0.895–1.315

0.406

1.191

0.979–1.449

0.080

  1. HbA1c hemoglobin A1c, HbA1c-SD standard deviation of HbA1c, HbA1c-CV coefficient of variation of HbA1c, E/e′ mitral Doppler early velocity/mitral annular early velocity, LVEF left ventricular ejection fraction, eGFR estimated glomerular filtration rate, ACEI/ARB angiotensin converting enzyme inhibitor/angiotensin II receptor blocker, BNP B-type natriuretic peptides, MI myocardial infarction, NYHA New York Heart Association functional class