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Table 4 Metformin concentrations in organs/tissues of different organisms after treatment

From: Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Organism Dose Time (h) Intestine (μmol/kg wet weight) Plasma (μmol/l) Liver (μmol/kg wet weight) Muscle (μmol/kg wet weight) Adipose tissue (μmol/kg wet weight) Stomach (μmol/kg wet weight) Kidney (μmol/kg wet weight) Refs
Human 2*850 mg; 6–8 weeks 3 4000 8–24       [30]
Human 2*850 mg; 6–8 weeks 12–16 250 < 8       [30]
Mice 1.25–1.5 mg (50 mg/kg) 0.5, 1, 2, 4, 8 3729; 5554; 3212; 2061; 803; IVC: 28.9; 28.1; 12.6; 14.7; 6.6
HPV: 51.7; 39; 19; 18.5; 9.3;
182, 154, 115, 37, 32 22, 28, 87, 58, 15 12, 14, 16, 11, 2 800, 965, 331, 129, 124 428, 246, 172, 121, 71 [184]
STZ diabetic mice 1.25–1.5 mg (50 mg/kg) 0.5, 1, 2, 4, 8 2161; 2585; 5546; 1261; 500 IVC: 35.4; 34.3; 21.5; 11.2
HPV: 61.5; 54.9; 28; 14.4; 8.9;
282, 137, 86, 53,32 66, 24, 16, 14, 16 42, 26, 75, 30, 20 541, 367, 783, 64, 52 384, 428, 229, 107, 63 [184]
Rat ~6 mg (50 mg/kg) 0.5   IVC: 14 49.6 ± 13.5      [15]
Rat ~6 mg (50 mg/kg) 4   IVC: 6.5 28.3 ± 7.3      [15]
  1. IVC inferior vena cava, HPV hepatic portal vein, STZ streptozotocin