Table 4 Metformin concentrations in organs/tissues of different organisms after treatment
Organism | Dose | Time (h) | Intestine (μmol/kg wet weight) | Plasma (μmol/l) | Liver (μmol/kg wet weight) | Muscle (μmol/kg wet weight) | Adipose tissue (μmol/kg wet weight) | Stomach (μmol/kg wet weight) | Kidney (μmol/kg wet weight) | Refs |
|---|---|---|---|---|---|---|---|---|---|---|
Human | 2*850 mg; 6–8 weeks | 3 | 4000 | 8–24 |  |  |  |  |  | [30] |
Human | 2*850 mg; 6–8 weeks | 12–16 | 250 | < 8 |  |  |  |  |  | [30] |
Mice | 1.25–1.5 mg (50 mg/kg) | 0.5, 1, 2, 4, 8 | 3729; 5554; 3212; 2061; 803; | IVC: 28.9; 28.1; 12.6; 14.7; 6.6 HPV: 51.7; 39; 19; 18.5; 9.3; | 182, 154, 115, 37, 32 | 22, 28, 87, 58, 15 | 12, 14, 16, 11, 2 | 800, 965, 331, 129, 124 | 428, 246, 172, 121, 71 | [184] |
STZ diabetic mice | 1.25–1.5 mg (50 mg/kg) | 0.5, 1, 2, 4, 8 | 2161; 2585; 5546; 1261; 500 | IVC: 35.4; 34.3; 21.5; 11.2 HPV: 61.5; 54.9; 28; 14.4; 8.9; | 282, 137, 86, 53,32 | 66, 24, 16, 14, 16 | 42, 26, 75, 30, 20 | 541, 367, 783, 64, 52 | 384, 428, 229, 107, 63 | [184] |
Rat | ~6 mg (50 mg/kg) | 0.5 |  | IVC: 14 | 49.6 ± 13.5 |  |  |  |  | [15] |
Rat | ~6 mg (50 mg/kg) | 4 |  | IVC: 6.5 | 28.3 ± 7.3 |  |  |  |  | [15] |