Inflammatory markers | No. of subjects | Diabetes | Cardiovascular disease | p value for equal associationsc | ||||
---|---|---|---|---|---|---|---|---|
Incidence | HR (95% CI)a | p b | Incidence | HR (95% CI)a | p b | |||
In MDCSd | ||||||||
Total leukocyte count | 25,969 | 3819 | 1.118 (1.082, 1.154) | < 0.001 | 4548 | 1.114 (1.081, 1.148) | < 0.001 | 0.888 |
Neutrophil count | 25,969 | 3819 | 1.086 (1.052, 1.121) | < 0.001 | 4548 | 1.108 (1.076, 1.140) | < 0.001 | 0.365 |
Lymphocyte count | 25,969 | 3819 | 1.092 (1.060, 1.124) | < 0.001 | 4548 | 1.040 (1.012, 1.070) | < 0.001 | 0.020 |
Mixed cell count | 25,969 | 3819 | 1.054 (1.021, 1.087) | < 0.001 | 4548 | 1.050 (1.020, 1.080) | < 0.001 | 0.862 |
NLR | 25,969 | 3819 | 0.998 (0.966, 1.032) | 0.929 | 4548 | 1.049 (1.020, 1.078) | < 0.001 | 0.025 |
In MDC–CVe | ||||||||
Ceruloplasmin | 4122 | 543 | 1.002 (0.912, 1.100) | 0.971 | 678 | 1.087 (1.002, 1.179) | 0.045 | 0.197 |
Alpha1-antitrypsin | 4299 | 583 | 1.025 (0.942, 1.116) | 0.565 | 709 | 1.113 (1.033, 1.199) | 0.005 | 0.154 |
Orosomucoid | 4322 | 591 | 1.118 (1.032, 1.211) | 0.006 | 716 | 1.088 (1.011, 1.171) | 0.024 | 0.626 |
Haptoglobin | 3991 | 520 | 1.110 (1.017, 1.210) | 0.019 | 651 | 1.061 (0.979, 1.149) | 0.149 | 0.455 |
C3 | 4369 | 598 | 1.250 (1.160, 1.347) | < 0.001 | 722 | 1.076 (0.997, 1.161) | 0.059 | 0.006 |
CRP | 4471 | 615 | 1.174 (1.076, 1.280) | < 0.001 | 729 | 1.116 (1.033, 1.206) | 0.005 | 0.396 |
SuPAR | 4509 | 618 | 1.041 (0.956, 1.133) | 0.360 | 751 | 1.137 (1.059, 1.221) | < 0.001 | 0.117 |