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Table 4 Comparison of risk of diabetes and cardiovascular disease in relation to inflammatory markers (multivariate analysis)

From: Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis

Inflammatory markers No. of subjects Diabetes Cardiovascular disease p value for equal associationsc
Incidence HR (95% CI)a p b Incidence HR (95% CI)a p b
In MDCSd
 Total leukocyte count 25,969 3819 1.118 (1.082, 1.154) < 0.001 4548 1.114 (1.081, 1.148) < 0.001 0.888
 Neutrophil count 25,969 3819 1.086 (1.052, 1.121) < 0.001 4548 1.108 (1.076, 1.140) < 0.001 0.365
 Lymphocyte count 25,969 3819 1.092 (1.060, 1.124) < 0.001 4548 1.040 (1.012, 1.070) < 0.001 0.020
 Mixed cell count 25,969 3819 1.054 (1.021, 1.087) < 0.001 4548 1.050 (1.020, 1.080) < 0.001 0.862
 NLR 25,969 3819 0.998 (0.966, 1.032) 0.929 4548 1.049 (1.020, 1.078) < 0.001 0.025
In MDC–CVe
 Ceruloplasmin 4122 543 1.002 (0.912, 1.100) 0.971 678 1.087 (1.002, 1.179) 0.045 0.197
 Alpha1-antitrypsin 4299 583 1.025 (0.942, 1.116) 0.565 709 1.113 (1.033, 1.199) 0.005 0.154
 Orosomucoid 4322 591 1.118 (1.032, 1.211) 0.006 716 1.088 (1.011, 1.171) 0.024 0.626
 Haptoglobin 3991 520 1.110 (1.017, 1.210) 0.019 651 1.061 (0.979, 1.149) 0.149 0.455
 C3 4369 598 1.250 (1.160, 1.347) < 0.001 722 1.076 (0.997, 1.161) 0.059 0.006
 CRP 4471 615 1.174 (1.076, 1.280) < 0.001 729 1.116 (1.033, 1.206) 0.005 0.396
 SuPAR 4509 618 1.041 (0.956, 1.133) 0.360 751 1.137 (1.059, 1.221) < 0.001 0.117
  1. HR hazard ratio, CI confidence interval, NLR neutrophil to lymphocyte ratio, CRP C-reactive protein, SuPAR soluble urokinase plasminogen activator receptor
  2. aAdjusted hazard ratios and 95% confidence intervals, per 1 standard deviation (all such values)
  3. bAnalysis by Cox proportional hazards model
  4. cp value associated with the null hypothesis that this variable has the same association with diabetes and cardiovascular disease, with all other effects being different; tests for all variables have 1 df
  5. dAdjusted for age, sex, waist circumference, smoking, systolic blood pressure, and anti-hypertensive drug medication
  6. eAdjusted for age, sex, waist circumference, smoking, systolic blood pressure, low-density lipoprotein, and anti-hypertensive drug medication