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Table 3 Comparison of risk of diabetes and cardiovascular disease in relation to inflammatory markers (age, sex-adjusted)

From: Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis

Inflammatory markers No. of subjects Diabetes Cardiovascular disease p value for equal associationsc
Incidence HR (95% CI)a p b Incidence HR (95% CI)a p b
In MDCS
 Total leukocyte count 25,969 3819 1.249 (1.214, 1.285) < 0.001 4548 1.235 (1.202, 1.269) < 0.001 0.572
 Neutrophil count 25,969 3819 1.182 (1.148, 1.216) < 0.001 4548 1.209 (1.177, 1.242) < 0.001 0.245
 Lymphocyte count 25,969 3819 1.171 (1.147, 1.196) < 0.001 4548 1.105 (1.081, 1.130) < 0.001 < 0.001
 Mixed cell count 25,969 3819 1.150 (1.116, 1.185) < 0.001 4548 1.109 (1.079, 1.140) < 0.001 0.080
 NLR 25,969 3819 0.981 (0.949, 1.014) 0.265 4548 1.058 (1.030, 1.088) < 0.001 < 0.001
In MDC–CV
 Ceruloplasmin 4122 543 1.056 (0.967, 1.153) 0.225 678 1.123 (1.040, 1.213) 0.003 0.300
 Alpha1-antitrypsin 4299 583 1.042 (0.959, 1.133) 0.330 709 1.167 (1.086, 1.254) < 0.001 0.044
 Orosomucoid 4322 591 1.290 (1.203, 1.384) < 0.001 716 1.185 (1.109, 1.267) < 0.001 0.087
 Haptoglobin 3991 520 1.235 (1.138, 1.339) < 0.001 651 1.171 (1.087, 1.262) < 0.001 0.351
 C3 4369 598 1.452 (1.362, 1.547) < 0.001 722 1.151 (1.075, 1.232) < 0.001 < 0.001
 CRP 4471 615 1.413 (1.306, 1.529) < 0.001 729 1.244 (1.157, 1.337) < 0.001 0.020
 SuPAR 4509 618 1.149 (1.068, 1.237) < 0.001 751 1.261 (1.184, 1.342) < 0.001 0.060
  1. HR hazard ratio, CI confidence interval, NLR neutrophil to lymphocyte ratio, CRP C-reactive protein, SuPAR soluble urokinase plasminogen activator receptor
  2. aAge- and sex-adjusted hazard ratios and 95% confidence intervals, per 1 standard deviation (all such values)
  3. bAnalysis by Cox proportional hazards model
  4. cp value associated with the null hypothesis that this variable has the same association with diabetes and cardiovascular disease, with all other effects being different; tests for all variables have 1 df