Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis

Table 3 Comparison of risk of diabetes and cardiovascular disease in relation to inflammatory markers (age, sex-adjusted)

Inflammatory markers	No. of subjects	Diabetes			Cardiovascular disease			p value for equal associations^c
Inflammatory markers	No. of subjects	Incidence	HR (95% CI)^a	p ^b	Incidence	HR (95% CI)^a	p ^b	p value for equal associations^c
In MDCS
Total leukocyte count	25,969	3819	1.249 (1.214, 1.285)	< 0.001	4548	1.235 (1.202, 1.269)	< 0.001	0.572
Neutrophil count	25,969	3819	1.182 (1.148, 1.216)	< 0.001	4548	1.209 (1.177, 1.242)	< 0.001	0.245
Lymphocyte count	25,969	3819	1.171 (1.147, 1.196)	< 0.001	4548	1.105 (1.081, 1.130)	< 0.001	< 0.001
Mixed cell count	25,969	3819	1.150 (1.116, 1.185)	< 0.001	4548	1.109 (1.079, 1.140)	< 0.001	0.080
NLR	25,969	3819	0.981 (0.949, 1.014)	0.265	4548	1.058 (1.030, 1.088)	< 0.001	< 0.001
In MDC–CV
Ceruloplasmin	4122	543	1.056 (0.967, 1.153)	0.225	678	1.123 (1.040, 1.213)	0.003	0.300
Alpha1-antitrypsin	4299	583	1.042 (0.959, 1.133)	0.330	709	1.167 (1.086, 1.254)	< 0.001	0.044
Orosomucoid	4322	591	1.290 (1.203, 1.384)	< 0.001	716	1.185 (1.109, 1.267)	< 0.001	0.087
Haptoglobin	3991	520	1.235 (1.138, 1.339)	< 0.001	651	1.171 (1.087, 1.262)	< 0.001	0.351
C3	4369	598	1.452 (1.362, 1.547)	< 0.001	722	1.151 (1.075, 1.232)	< 0.001	< 0.001
CRP	4471	615	1.413 (1.306, 1.529)	< 0.001	729	1.244 (1.157, 1.337)	< 0.001	0.020
SuPAR	4509	618	1.149 (1.068, 1.237)	< 0.001	751	1.261 (1.184, 1.342)	< 0.001	0.060

HR hazard ratio, CI confidence interval, NLR neutrophil to lymphocyte ratio, CRP C-reactive protein, SuPAR soluble urokinase plasminogen activator receptor
^aAge- and sex-adjusted hazard ratios and 95% confidence intervals, per 1 standard deviation (all such values)
^bAnalysis by Cox proportional hazards model
^cp value associated with the null hypothesis that this variable has the same association with diabetes and cardiovascular disease, with all other effects being different; tests for all variables have 1 df

ISSN: 1475-2840