In MDCS (n = 25,969) | Group1 without DM or CVD | Group2 incident DM alone | Group3 incident CVD alone | Group4 incident DM and CVD | p for trenda |
---|---|---|---|---|---|
n = 18,584 | n = 2837 | n = 3566 | n = 982 | ||
Age (years) | 57.3 (57.2, 57.4)b | 57.4 (57.1, 57.7)c | 61.8 (61.6, 62.1)c | 60.4 (59.9, 60.9) | < 0.001 |
Sex (male, %) | 33.1 | 44.3c | 52.7c | 56.4 | < 0.001 |
Waist circumference (cm) | 84.0 (83.9, 84.2) | 91.6 (91.2, 91.9)c | 85.2 (84.8, 85.5)c | 91.8 (91.2, 92.4) | < 0.001 |
Systolic blood pressure (mmHg) | 139.2 (138.9, 139.5) | 145.2 (144.5, 145.8)c | 143.9 (143.3, 144.5)c | 149.5 (148.4, 150.7) | < 0.001 |
Smokers (%) | 27.4 | 27.9c | 33.0c | 34.2 | < 0.001 |
Anti-hypertensive medication (%) | 12.4 | 24.2c | 21.2c | 31.2 | < 0.001 |
Total leukocyte count (109/L) | 6.23 (6.21, 6.26) | 6.59 (6.53, 6.66) | 6.58 (6.52, 6.63) | 6.82 (6.72, 6.92) | < 0.001 |
Neutrophil count (109/L) | 3.82 (3.80, 3.84) | 4.01 (3.96, 4.06)c | 4.07 (4.02, 4.11)c | 4.21 (4.13, 4.29) | < 0.001 |
Lymphocyte count (109/L) | 1.90 (1.89, 1.91) | 2.04 (2.02, 2.06)c | 1.98 (1.95, 2.00)c | 2.05 (2.01, 2.09) | < 0.001 |
Mixed cell count (109/L) | 0.517 (0.514, 0.520) | 0.541 (0.534, 0.549) | 0.537 (0.530, 0.543) | 0.558 (0.545, 0.571) | < 0.001 |
NLR | 2.15 (2.14, 2.17) | 2.10 (2.07, 2.14)c | 2.20 (2.17, 2.23)c | 2.18 (2.13, 2.24) | 0.004 |
In MDC–CV (n = 4658) | n = 3380 | n = 495 | n = 632 | n = 151 | |
---|---|---|---|---|---|
Age (years) | 56.9 (56.6, 57.1) | 56.7 (56.2, 57.2) | 60.1 (59.6, 60.5) | 59.3 (58.4, 60.2) | < 0.001 |
Sex (male, %) | 35.7 | 38.0c | 52.1c | 54.3 | < 0.001 |
Waist circumference (cm) | 83.3 (83.0, 83.6) | 88.7 (87.9, 89.5) | 84.4 (83.7, 85.2) | 90.2 (88.7, 91.6) | 0.007 |
Systolic blood pressure (mmHg) | 139.2 (138.6, 139.8) | 144.3 (142.7, 145.8) | 144.2 (142.9, 145.6) | 150.3 (147.5, 153.1) | < 0.001 |
Low-density lipoprotein cholesterol (mmol/L) | 4.12 (4.09, 4.16) | 4.30 (4.21, 4.38) | 4.19 (4.11, 4.27) | 4.33 (4.17, 4.48) | 0.112 |
Smokers (%) | 21.5 | 22.2c | 29.1c | 27.8 | < 0.001 |
Anti-hypertensive medication (%) | 11.0 | 21.2c | 18.7c | 25.2 | < 0.001 |
Ceruloplasmin (g/L) (missing = 536) | 0.500 (0.496, 0.505) | 0.503 (0.492, 0.514) | 0.513 (0.503, 0.523) | 0.516 (0.496, 0.537) | 0.020 |
Alpha1-antitrypsin (g/L) (missing = 359) | 1.20 (1.19, 1.21) | 1.20 (1.17, 1.22)c | 1.24 (1.22, 1.26)c | 1.24 (1.19, 1.29) | 0.002 |
Orosomucoid (g/L) (missing = 336) | 0.693 (0.685, 0.700) | 0.752 (0.732, 0.771) | 0.731 (0.714, 0.748) | 0.763 (0.728, 0.797) | < 0.001 |
Haptoglobin (g/L) (missing = 667) | 1.28 (1.26, 1.30) | 1.36 (1.31, 1.42) | 1.34 (1.29, 1.39) | 1.46 (1.36, 1.55) | 0.020 |
C3 (g/L) (missing = 289) | 1.50 (1.49, 1.51) | 1.66 (1.63, 1.69)c | 1.54 (1.52, 1.57)c | 1.68 (1.62, 1.73) | 0.004 |
CRP (mg/L) (missing = 187) | 2.25 (2.1, 2.39) | 3.09 (2.71, 3.47)c | 2.66 (2.31, 3.00)c | 3.75 (3.05, 4.46) | 0.030 |
SuPAR (ng/mL) (missing = 149) | 2.93 (2.9, 2.96) | 3.04 (2.96, 3.12) | 3.16 (3.08, 3.23) | 3.07 (2.92, 3.22) | < 0.001 |