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Table 1 Baseline characteristics according to incidence of diabetes (DM) and cardiovascular disease (CVD) during follow-up

From: Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis

In MDCS (n = 25,969)

Group1 without DM or CVD

Group2 incident DM alone

Group3 incident CVD alone

Group4 incident DM and CVD

p for trenda

n = 18,584

n = 2837

n = 3566

n = 982

Age (years)

57.3 (57.2, 57.4)b

57.4 (57.1, 57.7)c

61.8 (61.6, 62.1)c

60.4 (59.9, 60.9)

< 0.001

Sex (male, %)

33.1

44.3c

52.7c

56.4

< 0.001

Waist circumference (cm)

84.0 (83.9, 84.2)

91.6 (91.2, 91.9)c

85.2 (84.8, 85.5)c

91.8 (91.2, 92.4)

< 0.001

Systolic blood pressure (mmHg)

139.2 (138.9, 139.5)

145.2 (144.5, 145.8)c

143.9 (143.3, 144.5)c

149.5 (148.4, 150.7)

< 0.001

Smokers (%)

27.4

27.9c

33.0c

34.2

< 0.001

Anti-hypertensive medication (%)

12.4

24.2c

21.2c

31.2

< 0.001

Total leukocyte count (109/L)

6.23 (6.21, 6.26)

6.59 (6.53, 6.66)

6.58 (6.52, 6.63)

6.82 (6.72, 6.92)

< 0.001

Neutrophil count (109/L)

3.82 (3.80, 3.84)

4.01 (3.96, 4.06)c

4.07 (4.02, 4.11)c

4.21 (4.13, 4.29)

< 0.001

Lymphocyte count (109/L)

1.90 (1.89, 1.91)

2.04 (2.02, 2.06)c

1.98 (1.95, 2.00)c

2.05 (2.01, 2.09)

< 0.001

Mixed cell count (109/L)

0.517 (0.514, 0.520)

0.541 (0.534, 0.549)

0.537 (0.530, 0.543)

0.558 (0.545, 0.571)

< 0.001

NLR

2.15 (2.14, 2.17)

2.10 (2.07, 2.14)c

2.20 (2.17, 2.23)c

2.18 (2.13, 2.24)

0.004

In MDC–CV (n = 4658)

n = 3380

n = 495

n = 632

n = 151

 

Age (years)

56.9 (56.6, 57.1)

56.7 (56.2, 57.2)

60.1 (59.6, 60.5)

59.3 (58.4, 60.2)

< 0.001

Sex (male, %)

35.7

38.0c

52.1c

54.3

< 0.001

Waist circumference (cm)

83.3 (83.0, 83.6)

88.7 (87.9, 89.5)

84.4 (83.7, 85.2)

90.2 (88.7, 91.6)

0.007

Systolic blood pressure (mmHg)

139.2 (138.6, 139.8)

144.3 (142.7, 145.8)

144.2 (142.9, 145.6)

150.3 (147.5, 153.1)

< 0.001

Low-density lipoprotein cholesterol (mmol/L)

4.12 (4.09, 4.16)

4.30 (4.21, 4.38)

4.19 (4.11, 4.27)

4.33 (4.17, 4.48)

0.112

Smokers (%)

21.5

22.2c

29.1c

27.8

< 0.001

Anti-hypertensive medication (%)

11.0

21.2c

18.7c

25.2

< 0.001

Ceruloplasmin (g/L) (missing = 536)

0.500 (0.496, 0.505)

0.503 (0.492, 0.514)

0.513 (0.503, 0.523)

0.516 (0.496, 0.537)

0.020

Alpha1-antitrypsin (g/L) (missing = 359)

1.20 (1.19, 1.21)

1.20 (1.17, 1.22)c

1.24 (1.22, 1.26)c

1.24 (1.19, 1.29)

0.002

Orosomucoid (g/L) (missing = 336)

0.693 (0.685, 0.700)

0.752 (0.732, 0.771)

0.731 (0.714, 0.748)

0.763 (0.728, 0.797)

< 0.001

Haptoglobin (g/L) (missing = 667)

1.28 (1.26, 1.30)

1.36 (1.31, 1.42)

1.34 (1.29, 1.39)

1.46 (1.36, 1.55)

0.020

C3 (g/L) (missing = 289)

1.50 (1.49, 1.51)

1.66 (1.63, 1.69)c

1.54 (1.52, 1.57)c

1.68 (1.62, 1.73)

0.004

CRP (mg/L) (missing = 187)

2.25 (2.1, 2.39)

3.09 (2.71, 3.47)c

2.66 (2.31, 3.00)c

3.75 (3.05, 4.46)

0.030

SuPAR (ng/mL) (missing = 149)

2.93 (2.9, 2.96)

3.04 (2.96, 3.12)

3.16 (3.08, 3.23)

3.07 (2.92, 3.22)

< 0.001

  1. NLR neutrophil to lymphocyte ratio, CRP C-reactive protein, SuPAR soluble urokinase plasminogen activator receptor
  2. aAnalysis of covariance or multiple logistic regression analysis, adjusted for age and sex
  3. bGeometric mean (95% confidence interval) (all such values)
  4. cSignificant difference was found when participants with incident DM alone were compared with those with CVD alone