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Table 2 Bodyweight, blood glucose and echocardiographic assessment in non-diabetic (n = 10) and type 2 diabetic ZDF rats (n = 10)

From: Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

Parameter 12 weeks 20 weeks Condition effect (p value)
nDM DM nDM DM
ZDF rats
 Bodyweight (g) 3.1 ± 0.1 375.3 ± 36.7 387.2 ± 7.9 442.9 ± 46.2 0.04*
 Blood 8.6 ± 1.9 16.8 ± 2.5 8.2 ± 0.6 25.0 ± 2.5 0.01*
Glucose (mmol/L)
 LVPWs (mm) 3.1 ± 0.1 3.1 ± 0.1 2.9 ± 0.1 3.0 ± 0.1 0.60
 LVPWd (mm) 2.5 ± 0.1 2.5 ± 0.2 2.3 ± 0.1 2.7 ± 0.1 0.18
 EF (%) 77.2 ± 1.9 78.6 ± 1.2 72.2 ± 1.9 69.9 ± 3.9 0.84
 LVESV (mL) 0.2 ± 0.0 0.2 ± 0.0 0.3 ± 0.0 0.5 ± 0.1 0.21
 LVEDV (mL) 0.8 ± 0.1 1.0 ± 0.0 1.1 ± 0.1 1.4 ± 0.2 0.04*
 E:A 1.9 ± 0.1 2.0 ± 0.1 1.8 ± 0.1 2.0 ± 0.1 0.08
 E vel (cm/s) 1.9 ± 0.1 54.3 ± 2.2 55.1 ± 2.3 57.1 ± 3.0 0.52
 A vel (cm/s) 1.9 ± 0.1 27.4 ± 1.5 31.7 ± 2.1 29.2 ± 2.3 0.11
  1. Data are expressed ± SEM
  2. nDM nondiabetic, DM type 2 diabetic ZDF rats, LVPWs left ventricle posterior wall thickness systole, LVPWd left ventricle posterior wall thickness diastole, EF ejection fraction, LVESV end systolic volume, LVEDV end diastolic volume
  3. For comparison of condition effect between nDM and DM at 12 and 20 weeks of age in all parameters two between groups ANOVA, * p < 0.05