Skip to main content

Advertisement

Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

Fig. 6

No effect of diabetes or CaMKIIδ inhibition with KN93 on Ca2+ transient properties. a, b Representative confocal line scan images (upper) and normalized Ca2+ transients (lower) from non-diabetic (nDM) and diabetic (DM) cardiomyocytes in the presence of KN92 and KN93. c Mean Ca2+ transient amplitude (F/F0, where F0 is diastolic fluorescence). d Mean time constant of Ca2+ decay (Tau). e, f Representative confocal line scan images (upper) and normalized Ca2+ transients (lower) from nDM to diabetic (DM) cardiomyocytes in the presence of CTRL and AIP. g Mean Ca2+ transient amplitude. h Mean time constant of Ca2+ decay (Tau). Data are mean ± SEM. n = 13–17 cells. For all parameters two-way between groups ANOVA: treatment effect *p < 0.05

Back to article page