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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

Fig. 4

The CaMKII inhibitor KN93 restores developed force and partially restores rates of contraction and relaxation in trabeculae from ZDF rats. a Representative single twitches in the type 2 diabetic ZDF rat trabeculae in the presence of KN92 (straight black line) or KN93 (straight red line) at different stimulation frequencies. b Developed force (Fdev). c Maximum rate of contraction (dF/dtmax). d Maximum rate of relaxation (dF/dtmin). e Relaxation time from 50 to 90% relaxation (RT90%). Data are mean ± SEM. Non-diabetic ZDF rat KN92, dotted line, n = 9; Type 2 diabetic ZDF rat KN92, black straight line, n = 9; Type 2 diabetic ZDF rat KN93, red straight line, n = 7. Data are mean ± SEM. For all parameters two-way between groups ANOVA: condition effect, #p < 0.05 and treatment effect (KN93) *p < 0.05

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