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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

Fig. 2

CaMKIIδ activation is increased in right ventricular tissue from type 2 diabetic ZDF rats compared to non-diabetic controls. a Representative immunoblot of total CaMKIIδ, Thr287 phosphorylated (PCaMKIIδ) and GAPDH as a loading control in nDM and DM ZDF right ventricle tissue. b Quantification of total CaMKIIδ levels in nDM (n = 8) and DM (n = 8) ZDF right ventricle tissue. c Quantification of PCaMKIIδ levels in nDM (n = 8) and DM rats (n = 8). d Quantification of O-GlcNAc modified CaMKIIδ levels in non-diabetic nDM and DM ZDF right ventricular tissue (DM) (n = 5). Data are mean ± SEM. *p < 0.05 for comparison of nDM and DM values (unpaired t-test)

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