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Table 5 Mortality associated with cardiovascular disease in persons with type 2 diabetes

From: Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

Disease Author (year) Data collection period Patients n All deaths % CVD Deaths % Death rate % CVD proportion of all deaths
CVD Alwalkeel (2008) [30] Jan 1989–Jan 2004 T2DM adults 1952 161 8.20% 97 5.00% 60.20%
CVD Cardoso (2008) [31] 1994–96 to 2001 T2DM adults 471 121 25.70% 44 9.30% 36.40%
CVD Carnethon (2010) [32] 1989–93 to 2005 T2DM only 659 468 71.00% 211 32.0% 45.10%
CVD Carnethon (2010) [32] 1989–93 to 2005 CVD only 868 620 71.40% 304 35.0% 49.00%
CVD Carnethon (2010) [32] 1989–93 to 2005 T2DM + CVD 260 219 84.20% 129 49.60% 58.90%
CVD Carnethon (2010) [32] 1989–93 to 2005 No T2DM or CVD 3997 2095 52.40% 710 17.8% 33.90%
CVD Eeg-Olofsson (2010) [33] 1997–98 to 2003 T2DM adults 18,334 1902 10.40% 1456 7.90% 76.60%
CVD Malik (2015) [34] 2005–2011 T2DM adults 121,523 17,637 14.50% 3722 3.10% 21.10%
CVD Menzaghi (2014) [36] 2001–2008 GHS study—males 242 NR 42 17.40%
CVD Menzaghi (2014) [36] 2001–2008 GHS study—females 117 NR 16 13.70%
CVD Menzaghi (2014) [36] 1993–1999 HPFS study—males 833 NR 146 17.50%
CVD Menzaghi (2014) [36] 1976–1990 NMS study—females 902 NR 144 16.00%
CVD Salinero-Fort (2016) [35] 2007–08 to 2012 T2DM adults 2442 203 8.30% 96 3.90% 47.30%
CVD Salinero-Fort (2016) [35] 2007–08 to 2012 T2DM adults + kidney disease 965 221 22.90% 124 12.80% 56.10%
CVD Shestakova (2016) [29] 2015 T2DM adults 3,060,516 66,093 2.20% 30,560 1.00% 46.20%
  All CVD death   Patients with T2DM 3,208,557 86,557a 42.3%a 36,576a 9.9%a 50.3%a
CAD Cardoso (2008) [31] 1994–1996 to 2001 T2DM adults 471 121 25.70% 30 6.40% 24.80%
CAD Carnethon (2010) [32] 1989–1993 to 2005 T2DM only 659 468 71.00% 132 20.00% 28.20%
CAD Carnethon (2010) [32] 1989–1993 to 2005 CVD only 868 620 71.40% 213 24.50% 34.40%
CAD Carnethon (2010) [32] 1989–1993 to 2005 T2DM + CVD 260 219 84.20% 111 42.70% 50.70%
CAD Carnethon (2010) [32] 1989–1993 to 2005 No T2DM or CVD 3997 2095 52.40% 425 10.60% 20.30%
CAD Jackson (2012) [97] 2001–2007 Male diabetics 116,145 22,033 19.00% 6000 5.20% 27.20%
CAD Jackson (2012) [97] 2001–2007 Male non-diabetics 2,433,748    36,801 1.50%  
CAD Jackson (2012) [97] 2001–2007 Female diabetics 100,507 20,571 20.50% 4554 4.50% 22.10%
CAD Jackson (2012) [97] 2001–2007 Female non-diabetics 2,630,482    32,449 1.20%  
  All CAD death   Patients with T2DM 218,462a 42,944a 24.9%a 10,695a 6.3%a 29.7%a
CHF Mazza (2007) [104] 1983–1985 to 1997 Male diabetics 202 22 10.90%
CHF Mazza (2007) [104] 1983–1985 to 1997 Female diabetics 379 29 7.70%
CHF Mazza (2007) [104] 1983–1985 to 1997 All 581 369 63.50% 13.80%
CHF Shestakova (2016) [29] 2015 T2DM adults 3,060,516 66,093 2.20% 18,963 0.60% 28.70%
  All CHF deaths   Patients with T2DM 3,061,097a 66,093a 2.2%a 1,9104a 6.1%a 28.7%a
MI Shestakova (2016) [29] 2015 T2DM adults 3,060,516 66,093 2.20% 3393 0.10% 5.10%
SCD Kucharska-Newton (2010) [99] 1987–89 to 2001 T2DM adults 1550 NR 69 4.50%
SCD Kucharska-Newton (2010) [99] 1987–89 to 2001 No T2DM 12,428 NR 140 1.10%
Stroke Jackson (2012) [97] 2001–2007 Male diabetics 116,145 22,033 19.00% 1942 1.70% 8.80%
Stroke Jackson (2012) [97] 2001–2007 Male non-diabetics 2,433,748    13,191 0.50%  
Stroke Jackson (2012) [97] 2001–2007 Female diabetics 100,507 20,571 20.50% 2436 2.40% 11.80%
Stroke Jackson (2012) [97] 2001–2007 Female non-diabetics 2,630,482    23,632 0.90%  
Stroke Shestakova (2016) [29] 2015 T2DM adults 3,060,516 66,093 2.20% 8204 0.30% 12.40%
  All CBV deaths   Patients with T2DM 327,168a 108,697a 3.30% 12,582a 1.50% 11.0%a
  1. CAD coronary artery disease (variously reported as coronary heart disease or ischemic heart disease), CBV cerebrovascular disease, CHF congestive heart failure (also reported simply as heart failure), CVD cardiovascular disease, MI myocardial infarction, NR not reported, SCD sudden cardiac death, T2DM type 2 diabetes mellitus
  2. aWeighted average of rates taken only for patients with T2DM and where complete outcomes were reported; thus, the number does not represent the sum of all of the numbers in the column above it