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Table 2 Hazard ratios for CVD and non-CVD mortality in women and men stratified by BMI categories

From: Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife

  BMI (kg/m2) Total or BMI as a continuous variable
< 18.5 18.50–21.99 22.0–24.99 25.0–29.99 ≥ 30.0
Women
N of participants 128,876 448,712 224,937 99,867 25,476 927,868
Median follow-up (25th; 75th) 16.4 (10.0, 25.6) 18.0 (9.7, 27.9) 17.9 (9.6, 27.9) 15.9 (8.3, 24.8) 11.9 (6.0, 19.5) 17.4 (9.3, 27.0)
Cumulative follow-up (person-years) 2,301,449 8,641,690 4,305,855 1,745,031 352,203 17,346,230
Cardiovascular mortality (451 deaths)
N of deaths 31 189 134 76 21 451
Crude incidence (per 105 person years) 1.34 2.18 3.11 4.35 5.96 2.59
HR 0.68 1 (ref) 1.42 2.13 3.90 1.12 3
95% CI 0.46–0.98 1.14–1.77 1.63–2.78 2.47–6.14 1.096–1.151
p 0.043 0.002 2.9*10−8 4.4*10−9 3.3*10−20
Non-cardiovascular mortality (6235 deaths)
N of deaths 741 3008 1621 707 158 6235
Crude incidence 32.19 34.80 37.64 40.51 44.86 35.94
HR 1.01 1 (ref) 1.07 1.23 1.66 1.031
95% CI 0.93–1.10 1.01–1.14 1.13–1.33 1.42–1.95 1.02–1.04
P 0.80 0.021 10−6 5.3*10−10 4.8*10−14
Men
N of participants 186,190 678,005 324,665 139,556 37,855 1,366,271
Median follow-up (25th; 75th) 19.4 (10.9, 29.8) 20.4 (11.3, 31.9) 19.3 (10.1, 31.1) 16.1 (8.1, 26.9) 11.5 (5.9, 20.1) 19.4 (10.4, 30.8)
Cumulative follow-up (person-years) 3,834,407 14,685,322 6,744,963 2,555,251 547,485 28,367,431
Cardiovascular mortality (3208 deaths)
N of deaths 306 1284 865 578 175 3208
Crude incidence (per 105 person years) 7.98 8.74 12.82 22.62 31.96 11.30
HR 0.99 1 (ref) 1.53 2.99 5.40 1.14
95% CI 0.88–1.13 1.40–1.67 2.71–3.31 4.60–6.33 1.13–1.15
p 0.93 8.7*10−22 10−103 1.8*10−95 3.7*10−169
Non-cardiovascular mortality (22,233 deaths)
N of deaths 2970 11,184 5358 2158 563 22,233
Crude incidence (per 105 person years) 77.45 76.15 79.43 84.45 102.83 78.37
HR 1.04 1 (ref) 1.06 1.16 1.48 1.019
95% CI 1.00–1.09 1.03–1.10 1.11–1.21 1.36–1.61 1.01–1.02
p 0.040 0.0003 6.1*10−10 1.8*10−19 2.6*10−17
  1. The association was assessed with Cox models adjusted for age, sex, birth year, residential socio-economic status, education, country of origin, and height