| BMI (kg/m2) | Total or BMI as a continuous variable | ||||
---|---|---|---|---|---|---|
< 18.5 | 18.50–21.99 | 22.0–24.99 | 25.0–29.99 | ≥ 30.0 | ||
Women | ||||||
N of participants | 128,876 | 448,712 | 224,937 | 99,867 | 25,476 | 927,868 |
Median follow-up (25th; 75th) | 16.4 (10.0, 25.6) | 18.0 (9.7, 27.9) | 17.9 (9.6, 27.9) | 15.9 (8.3, 24.8) | 11.9 (6.0, 19.5) | 17.4 (9.3, 27.0) |
Cumulative follow-up (person-years) | 2,301,449 | 8,641,690 | 4,305,855 | 1,745,031 | 352,203 | 17,346,230 |
Cardiovascular mortality (451 deaths) | ||||||
N of deaths | 31 | 189 | 134 | 76 | 21 | 451 |
Crude incidence (per 105 person years) | 1.34 | 2.18 | 3.11 | 4.35 | 5.96 | 2.59 |
HR | 0.68 | 1 (ref) | 1.42 | 2.13 | 3.90 | 1.12 3 |
95% CI | 0.46–0.98 | 1.14–1.77 | 1.63–2.78 | 2.47–6.14 | 1.096–1.151 | |
p | 0.043 | 0.002 | 2.9*10−8 | 4.4*10−9 | 3.3*10−20 | |
Non-cardiovascular mortality (6235 deaths) | ||||||
N of deaths | 741 | 3008 | 1621 | 707 | 158 | 6235 |
Crude incidence | 32.19 | 34.80 | 37.64 | 40.51 | 44.86 | 35.94 |
HR | 1.01 | 1 (ref) | 1.07 | 1.23 | 1.66 | 1.031 |
95% CI | 0.93–1.10 | 1.01–1.14 | 1.13–1.33 | 1.42–1.95 | 1.02–1.04 | |
P | 0.80 | 0.021 | 10−6 | 5.3*10−10 | 4.8*10−14 | |
Men | ||||||
N of participants | 186,190 | 678,005 | 324,665 | 139,556 | 37,855 | 1,366,271 |
Median follow-up (25th; 75th) | 19.4 (10.9, 29.8) | 20.4 (11.3, 31.9) | 19.3 (10.1, 31.1) | 16.1 (8.1, 26.9) | 11.5 (5.9, 20.1) | 19.4 (10.4, 30.8) |
Cumulative follow-up (person-years) | 3,834,407 | 14,685,322 | 6,744,963 | 2,555,251 | 547,485 | 28,367,431 |
Cardiovascular mortality (3208 deaths) | ||||||
N of deaths | 306 | 1284 | 865 | 578 | 175 | 3208 |
Crude incidence (per 105 person years) | 7.98 | 8.74 | 12.82 | 22.62 | 31.96 | 11.30 |
HR | 0.99 | 1 (ref) | 1.53 | 2.99 | 5.40 | 1.14 |
95% CI | 0.88–1.13 | 1.40–1.67 | 2.71–3.31 | 4.60–6.33 | 1.13–1.15 | |
p | 0.93 | 8.7*10−22 | 10−103 | 1.8*10−95 | 3.7*10−169 | |
Non-cardiovascular mortality (22,233 deaths) | ||||||
N of deaths | 2970 | 11,184 | 5358 | 2158 | 563 | 22,233 |
Crude incidence (per 105 person years) | 77.45 | 76.15 | 79.43 | 84.45 | 102.83 | 78.37 |
HR | 1.04 | 1 (ref) | 1.06 | 1.16 | 1.48 | 1.019 |
95% CI | 1.00–1.09 | 1.03–1.10 | 1.11–1.21 | 1.36–1.61 | 1.01–1.02 | |
p | 0.040 | 0.0003 | 6.1*10−10 | 1.8*10−19 | 2.6*10−17 |