|
Male gender
|
5.29 (2.38–11.75)
|
< 0.0001
|
|
Age (years)
|
1.03 (1.00–1.06)
|
0.031
|
|
BMI (kg/m2)
|
0.97 (0.92–1.01)
|
0.185
|
|
Active smoking
|
1.82 (0.91–3.63)
|
0.089
|
|
Heart rate (bpm)
|
0.99 (0.97–1.01)
|
0.643
|
|
SBP (mmHg)
|
1.03 (1.01–1.04)
|
0.0001
|
|
DBP (mmHg)
|
1.00 (0.98–1.03)
|
0.596
|
|
Diabetes duration (per year)
|
1.03 (1.01–1.06)
|
0.014
|
|
LDL-cholesterol (mmol/l)
|
1.24 (0.60–2.57)
|
0.554
|
|
HbA1c (%)
|
0.88 (0.72–1.07)
|
0.217
|
|
eGFR, ml min−1 (1.73 m)−2
|
0.97 (0.96–0.98)
|
< 0.0001
|
|
Microangiopathy components
|
|
uACR (reference < 3 mg/mmol)a
| |
< 0.0001
|
|
3–30 mg/mmol
|
2.12 (0.91–4.89)
| |
|
> 30 mg/mmol
|
6.64 (3.11–14.20)
| |
|
Severe diabetic retinopathy
|
2.51 (1.35–4.64)
|
0.003
|
|
Macular edema
|
2.13 (1.07–4.25)
|
0.032
|
|
Macroangiopathy components
|
|
Ischemic heart disease
|
1.14 (0.62–2.12)
|
0.667
|
|
Carotid artery disease
|
1.15 (0.54–2.45)
|
0.715
|
|
Peripheral artery disease
|
12.05 (6.87–21.12)
|
< 0.0001
|
|
Biological markers
|
|
TNFR1α (per 10 log pg/ml)
|
1.37 (1.26–1.48)
|
<0.0001
|
|
ANGPTL2 (per 10 log ng/ml)
|
1.33 (1.20–1.48)
|
< 0.0001
|
