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Table 3 Clinical and biological characteristics associated with incidence of major amputation
| Variables | HR (95% CI) | p value |
|---|---|---|
| Male gender | 5.29 (2.38–11.75) | < 0.0001 |
| Age (years) | 1.03 (1.00–1.06) | 0.031 |
| BMI (kg/m2) | 0.97 (0.92–1.01) | 0.185 |
| Active smoking | 1.82 (0.91–3.63) | 0.089 |
| Heart rate (bpm) | 0.99 (0.97–1.01) | 0.643 |
| SBP (mmHg) | 1.03 (1.01–1.04) | 0.0001 |
| DBP (mmHg) | 1.00 (0.98–1.03) | 0.596 |
| Diabetes duration (per year) | 1.03 (1.01–1.06) | 0.014 |
| LDL-cholesterol (mmol/l) | 1.24 (0.60–2.57) | 0.554 |
| HbA1c (%) | 0.88 (0.72–1.07) | 0.217 |
| eGFR, ml min−1 (1.73 m)−2 | 0.97 (0.96–0.98) | < 0.0001 |
| Microangiopathy components | ||
| uACR (reference < 3 mg/mmol)a | < 0.0001 | |
| 3–30 mg/mmol | 2.12 (0.91–4.89) | |
| > 30 mg/mmol | 6.64 (3.11–14.20) | |
| Severe diabetic retinopathy | 2.51 (1.35–4.64) | 0.003 |
| Macular edema | 2.13 (1.07–4.25) | 0.032 |
| Macroangiopathy components | ||
| Ischemic heart disease | 1.14 (0.62–2.12) | 0.667 |
| Carotid artery disease | 1.15 (0.54–2.45) | 0.715 |
| Peripheral artery disease | 12.05 (6.87–21.12) | < 0.0001 |
| Biological markers | ||
| TNFR1α (per 10 log pg/ml) | 1.37 (1.26–1.48) | <0.0001 |
| ANGPTL2 (per 10 log ng/ml) | 1.33 (1.20–1.48) | < 0.0001 |
