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Table 2 Cox multivariate analysis for the risk of minor amputation

From: Influence of micro- and macro-vascular disease and Tumor Necrosis Factor Receptor 1 on the level of lower-extremity amputation in patients with type 2 diabetes

  Maximal model Final model
HR (95% CI) p value HR (95% CI) p value
Sex (ref. women) 8.29 (1.93–35.49) 0.004 10.12 (2.41–42.56) 0.0016
SBP (mmHg) 1.02 (0.99–1.04) 0.157   
DBP (mmHg) 1.01 (0.97–1.05) 0.552   
eGFR, ml min−1 (1.73 m)−2 1.01 (0.99–1.03) 0.331   
uACR (reference < 3 mg/mmol)a   0.840   
 3–30 1.36 (0.48–3.83)    
 > 30 1.22 (0.38–3.92)    
Severe diabetic retinopathy (vs. no) 3.50 (1.36–8.99) 0.009 2.69 (1.31–5.57) 0.0073
Macular edema (vs. no) 0.92 (0.34–2.49) 0.879   
History of PAD (vs. no) 5.38 (2.43–11.91) < 0.001 4.37 (2.11–9.07) < 0.001
TNFR1 (per 10 log pg/ml) 1.11 (0.88–1.41) 0.396   
ANGPTL2 (per 10 log ng/ml) 1.17 (0.95–1.46) 0.135 1.25 (1.08–1.45) 0.0025
  1. Variables associated with minor amputation at p < 0.05 in the univariate Cox model were selected for the multivariate ‘maximal model’. The ‘final model’ was determined using multiple backward stepwise regression analysis applied to the ‘maximal model’. Italic data indicate p values below the statistical significance threshold
  2. SBP systolic blood pressure, DBP diastolic blood pressure, PAD peripheral artery disease, uACR urine albumin-to-creatinine ratio
  3. a Missing data at baseline for 149 patients