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Table 2 Cox multivariate analysis for the risk of minor amputation

From: Influence of micro- and macro-vascular disease and Tumor Necrosis Factor Receptor 1 on the level of lower-extremity amputation in patients with type 2 diabetes

 

Maximal model

Final model

HR (95% CI)

p value

HR (95% CI)

p value

Sex (ref. women)

8.29 (1.93–35.49)

0.004

10.12 (2.41–42.56)

0.0016

SBP (mmHg)

1.02 (0.99–1.04)

0.157

  

DBP (mmHg)

1.01 (0.97–1.05)

0.552

  

eGFR, ml min−1 (1.73 m)−2

1.01 (0.99–1.03)

0.331

  

uACR (reference < 3 mg/mmol)a

 

0.840

  

 3–30

1.36 (0.48–3.83)

   

 > 30

1.22 (0.38–3.92)

   

Severe diabetic retinopathy (vs. no)

3.50 (1.36–8.99)

0.009

2.69 (1.31–5.57)

0.0073

Macular edema (vs. no)

0.92 (0.34–2.49)

0.879

  

History of PAD (vs. no)

5.38 (2.43–11.91)

< 0.001

4.37 (2.11–9.07)

< 0.001

TNFR1 (per 10 log pg/ml)

1.11 (0.88–1.41)

0.396

  

ANGPTL2 (per 10 log ng/ml)

1.17 (0.95–1.46)

0.135

1.25 (1.08–1.45)

0.0025

  1. Variables associated with minor amputation at p < 0.05 in the univariate Cox model were selected for the multivariate ‘maximal model’. The ‘final model’ was determined using multiple backward stepwise regression analysis applied to the ‘maximal model’. Italic data indicate p values below the statistical significance threshold
  2. SBP systolic blood pressure, DBP diastolic blood pressure, PAD peripheral artery disease, uACR urine albumin-to-creatinine ratio
  3. a Missing data at baseline for 149 patients