Variable | HR (95% CI) | p value |
---|---|---|
Male gender | 5.28 (2.05–13.57) | 0.0005 |
Age (per year) | 1.02 (0.98–1.05) | 0.198 |
BMI, kg/m2 | 0.99 (0.94–1.04) | 0.740 |
Active smoking | 1.01 (0.36–2.85) | 0.984 |
Heart rate (bpm) | 1.01 (0.98–1.03) | 0.417 |
SBP (mmHg) | 1.03 (1.01–1.05) | 0.0003 |
DBP (mmHg) | 1.04 (1.00–1.06) | 0.015 |
Diabetes duration (per year) | 1.01 (0.98–1.05) | 0.425 |
LDL-cholesterol (mmol/l) | 2.77 (0.31–25.00) | 0.364 |
HbA1c (%) | 1.05 (0.85–1.29) | 0.663 |
eGFR, ml min−1 (1.73 m)−2 | 0.98 (0.97–0.99) | 0.008 |
Microangiopathy components | ||
uACR (reference < 3 mg/mmol)a | 0.0007 | |
3–30 mg/mmol | 2.15 (0.83–5.55) | |
> 30 mg/mmol | 5.20 (2.15–12.55) | |
Severe diabetic retinopathy | 4.14 (2.10–8.15) | < 0.0001 |
Macular edema | 3.49 (1.66–7.34) | 0.001 |
Macroangiopathy components | ||
Ischemic heart disease | 1.09 (0.53–2.26) | 0.805 |
Carotid artery disease | 1.98 (0.91–4.36) | 0.085 |
Peripheral artery disease | 6.86 (3.41–13.81) | < 0.0001 |
Biological markers | ||
TNFR1α (per 10 log pg/ml) | 1.29 (1.14–1.46) | < 0.0001 |
ANGPTL2 (per 10 log ng/ml) | 1.29 (1.16–1.43) | < 0.0001 |