Fig. 3

Cumulative percentage of major amputation according to micro- or macrovascular disease. a History of microvascular disease; absence (dashed line), presence (black line). P Log-rank = 0.0003. Microvascular disease was defined as elevated increased urinary albumin–creatinine ratio and/or severe DR and/or macular edema. b History of non-peripheral macrovascular disease; absence (dashed line), presence (black line). P Log-rank = 0.595. c History of PAD; absence (dashed line), presence (black line). P Log-rank < 0.0001. PAD peripheral artery disease. p Log-rank < 0.05 was considered significant