Study group 1 (explorative analysis) | |||||||||
---|---|---|---|---|---|---|---|---|---|
T2DM n = 18 | Non-DM n = 30 | P | T2DM (− Met) n = 8 | Non-DM n = 30 | P | T2DM (+ Met) n = 10 | T2DM (− Met) n = 8 | P | |
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||||
Age at surgery, years | 66.61 ± 7.51 | 63.60 ± 8.98 | 0.219 | 67.13 ± 8.63 | 63.60 ± 8.98 | 0.330 | 66.20 ± 6.94 | 67.13 ± 8.63 | 0.809 |
HbA1c, % | 6.94 ± 1.21 | 5.74 ± 0.38 | 0.002 | 7.37 ± 1.52 | 5.74 ± 0.38 | 0.029 | 6.56 ± 0.76 | 7.37 ± 1.52 | 0.236 |
HbA1c, mmol/mol | 52.28 ± 13.07 | 39.21 ± 4.08 | 0.002 | 56.93 ± 16.41 | 39.21 ± 4.08 | 0.029 | 48.21 ± 8.36 | 56.93 ± 16.41 | 0.238 |
Cholesterol, mmol/L | 4.19 ± 1.11 | 4.45 ± 1.16 | 0.486 | 4.27 ± 1.16 | 4.45 ± 1.16 | 0.721 | 4.11 ± 1.14 | 4.27 ± 1.16 | 0.803 |
LDL, mmol/L | 2.31 ± 0.70 | 2.61 ± 1.01 | 0.267 | 2.41 ± 0.76 | 2.61 ± 1.01 | 0.571 | 2.21 ± 0.68 | 2.41 ± 0.76 | 0.614 |
HDL, mmol/L | 1.16 ± 0.38 | 1.21 ± 0.33 | 0.684 | 1.01 ± 0.24 | 1.21 ± 0.33 | 0.101 | 1.30 ± 0.46 | 1.01 ± 0.24 | 0.168 |
Triglycerides, mmol/L | 1.88 ± 1.21 | 1.45 ± 0.63 | 0.210 | 2.23 ± 1.54 | 1.45 ± 0.63 | 0.234 | 1.58 ± 0.81 | 2.23 ± 1.54 | 0.344 |
Creatinine, µmol/L | 83.72 ± 15.42 | 85.70 ± 13.14 | 0.653 | 76.88 ± 11.22 | 85.70 ± 13.14 | 0.080 | 89.20 ± 16.62 | 76.88 ± 11.22 | 0.080 |
BMI, kg/m2 | 29.98 ± 3.06 | 27.26 ± 3.77 | 0.010 | 29.24 ± 2.57 | 27.26 ± 3.77 | 0.104 | 30.57 ± 3.42 | 29.24 ± 2.57 | 0.360 |
SBP, mm Hg | 134.22 ± 19.47 | 138.42 ± 22.13 | 0.510 | 141.38 ± 22.36 | 138.42 ± 22.13 | 0.749 | 128.50 ± 15.66 | 141.38 ± 22.36 | 0.192 |
DBP, mm Hg | 75.06 ± 11.61 | 77.70 ± 12.78 | 0.476 | 80.00 ± 14.63 | 77.70 ± 12.78 | 0.697 | 71.10 ± 7.02 | 80.00 ± 14.63 | 0.146 |
Male sex, % | 100 | 100 | … | 100 | 100 | … | 100 | 100 | … |
Statins, n | 18 | 30 | … | 8 | 30 | … | 10 | 8 | … |
Antihypertensives, n | 17 | 26 | 0.637 | 7 | 26 | 1.000 | 10 | 7 | 0.444 |
Insulins, n | 6 | 0 | 0.002 | 4 | 0 | < 0.001 | 2 | 4 | 0.321 |
Oral antidiabetic agents, n | 12 | 0 | < 0.001 | 2 | 0 | 0.040 | 10 | 2 | 0.002 |
Study group 2 (targeted analysis) | |||||||||
---|---|---|---|---|---|---|---|---|---|
T2DM n = 26 | Non-DM n = 26 | P | T2DM (− Met) n = 11 | Non-DM n = 26 | P | T2DM (+ Met) n = 15 | T2DM (− Met) n = 11 | P | |
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||||
Age at surgery, years | 67.84 ± 4.83 | 68.99 ± 5.24 | 0.410 | 67.35 ± 4.21 | 68.99 ± 5.24 | 0.367 | 68.25 ± 5.35 | 67.35 ± 4.21 | 0.670 |
HbA1c, % | 7.11 ± 1.11 | 5.60 ± 0.37 | < 0.001 | 7.41 ± 1.39 | 5.60 ± 0.37 | < 0.001 | 6.84 ± 0.75 | 7.41 ± 1.39 | 0.231 |
HbA1c, mmol/mol | 54.24 ± 12.17 | 37.71 ± 4.03 | < 0.001 | 57.48 ± 15.19 | 37.71 ± 4.03 | < 0.001 | 51.28 ± 8.16 | 57.48 ± 15.19 | 0.230 |
Cholesterol, mmol/L | 3.76 ± 1.04 | 4.20 ± 1.26 | 0.230 | 4.00 ± 1.32 | 4.20 ± 1.26 | 0.692 | 3.55 ± 0.68 | 4.00 ± 1.32 | 0.329 |
LDL, mmol/L | 1.85 ± 0.69 | 2.33 ± 0.90 | 0.058 | 2.07 ± 0.87 | 2.33 ± 0.90 | 0.447 | 1.65 ± 0.42 | 2.07 ± 0.87 | 0.174 |
HDL, mmol/L | 1.13 ± 0.24 | 1.41 ± 0.51 | 0.030 | 1.14 ± 0.25 | 1.41 ± 0.51 | 0.129 | 1.12 ± 0.25 | 1.14 ± 0.25 | 0.851 |
Triglycerides, mmol/L | 1.90 ± 0.89 | 1.21 ± 0.35 | 0.002 | 1.89 ± 1.03 | 1.21 ± 0.35 | 0.011 | 1.91 ± 0.79 | 1.89 ± 1.03 | 0.960 |
Creatinine, µmol/L | 96.12 ± 29.47 | 86.40 ± 16.93 | 0.160 | 95.64 ± 32.61 | 86.40 ± 16.93 | 0.269 | 96.47 ± 28.12 | 95.64 ± 32.61 | 0.945 |
BMI, kg/m2 | 28.66 ± 3.95 | 27.13 ± 3.69 | 0.150 | 27.21 ± 3.41 | 27.13 ± 3.69 | 0.949 | 29.73 ± 4.08 | 27.21 ± 3.41 | 0.110 |
SBP, mm Hg | 141.12 ± 18.64 | 139.92 ± 19.79 | 0.820 | 138.82 ± 10.59 | 139.92 ± 19.79 | 0.863 | 142.80 ± 23.09 | 138.82 ± 10.59 | 0.601 |
DBP, mm Hg | 74.92 ± 10.42 | 77.73 ± 10.71 | 0.340 | 75.73 ± 12.28 | 77.73 ± 10.71 | 0.621 | 74.33 ± 9.24 | 75.73 ± 12.28 | 0.744 |
Male sex, % | 85 | 85 | … | 82 | 85 | … | 87 | 82 | … |
Statins, n | 26 | 26 | … | 11 | 26 | … | 15 | 11 | … |
Antihypertensives, n | 21 | 13 | 0.040 | 8 | 13 | 0.285 | 13 | 8 | 0.620 |
Insulins, n | 6 | 0 | 0.023 | 3 | 0 | 0.021 | 3 | 3 | 0.218 |
Oral antidiabetic agents, n | 19 | 0 | < 0.001 | 4 | 0 | 0.005 | 15 | 4 | < 0.001 |