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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart

Fig. 2

The combination of Hif1a haploinsufficiency and maternal diabetes exposure alters echocardiographic parameters of the offspring. Representative M-mode recordings of LV structures in long axes view in a Wt males from non-diabetic pregnancy and b Hif1a+/ males from diabetic pregnancy. c, d The echocardiographic evaluation of LV systolic function, fractional shortening (FS), in the 1- and 12-week-old male offspring. e, f The heart rate in Wt and Hif1a+/ males from both diabetic and non-diabetic pregnancies at 1 and 12 weeks of age. The values are mean ± SEM (1-week-old: n = 20 Wt from non-diabetic pregnancy; n = 14 Wt from diabetic pregnancy; n = 17 Hif1a+/ from non-diabetic pregnancy; n = 9 Hif1a+/ from diabetic pregnancy; 12-week-old: n = 20 Wt from non-diabetic pregnancy; n = 15 Wt from diabetic pregnancy and Hif1a+/ from non-diabetic pregnancy; n = 10 Hif1a+/ from diabetic pregnancy). Statistical significance assessed by two-way ANOVA: genotype effect (FS% P < 0.001); and diabetes effect (FS% P < 0.0001; heart rate, P < 0.0001). *Significant differences by post hoc Tukey’s multiple-comparison test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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