TY - JOUR AU - Cerychova, Radka AU - Bohuslavova, Romana AU - Papousek, Frantisek AU - Sedmera, David AU - Abaffy, Pavel AU - Benes, Vladimir AU - Kolar, Frantisek AU - Pavlinkova, Gabriela PY - 2018 DA - 2018/05/12 TI - Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart JO - Cardiovascular Diabetology SP - 68 VL - 17 IS - 1 AB - Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition remain poorly understood. We examined whether hypoxia-inducible factor 1 alpha, in combination with exposure to a diabetic intrauterine environment, influences the function and molecular structure of the adult offspring heart. SN - 1475-2840 UR - https://doi.org/10.1186/s12933-018-0713-0 DO - 10.1186/s12933-018-0713-0 ID - Cerychova2018 ER -