| |
Composite endpoint
|
All-cause mortality
|
Readmission due to HF
|
|---|
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
|---|
|
PAPP-A
|
|
Univariable
|
1.25 (1.09–1.42)
|
0.001
|
1.30 (1.12–1.51)
|
0.001
|
1.08 (0.85–1.38)
|
0.525
|
|
Adjusted
|
1.13 (0.94–1.35)
|
0.185
|
1.10 (0.90–1.35)
|
0.340
|
0.94 (0.65–1.35)
|
0.729
|
|
Stanniocalcin-2
|
|
Univariable
|
2.90 (1.81–4.64)
|
< 0.001
|
2.52 (1.47–4.29)
|
0.001
|
5.37 (2.35–12.26)
|
< 0.001
|
|
Adjusted
|
2.06 (1.13–3.75)
|
0.018
|
2.23 (1.16–4.29)
|
0.017
|
3.42 (1.22–9.60)
|
0.020
|
|
IGFBP-4
|
|
Univariable
|
3.29 (2.47–4.39)
|
< 0.001
|
3.18 (2.30–4.39)
|
< 0.001
|
2.69 (1.83–3.97)
|
< 0.001
|
|
Adjusted
|
1.73 (1.14–2.64)
|
0.010
|
1.44 (0.85–2.44)
|
0.170
|
0.82 (0.42–1.60)
|
0.562
|
|
Hs-TnT
|
|
Univariable
|
1.48 (1.32–1.65)
|
< 0.001
|
1.44 (1.27–1.63)
|
< 0.001
|
1.64 (1.36–1.98)
|
< 0.001
|
|
Adjusted
|
1.07 (0.91–1.25)
|
0.424
|
1.04 (0.87–1.25)
|
0.665
|
1.00 (0.81–1.26)
|
0.959
|
|
NT-ProBNP
|
|
Univariable
|
1.69 (1.54–1.84)
|
< 0.001
|
1.66 (1.50–1.84)
|
< 0.001
|
1.68 (1.43–1.97)
|
< 0.001
|
|
Adjusted
|
1.21 (1.07–1.37)
|
0.002
|
1.18 (1.02–1.36)
|
0.028
|
1.24 (0.92–1.68)
|
0.157
|
- All HRs (95% CIs) are reported per 1-SD increment of natural log-transformed plasma levels
- hs-TnT high-sensitivity troponin T, PAPP-A pregnancy-associated plasma protein-A, IGFBP-4 insulin-like growth factor binding protein-4
