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Table 3 Univariable and multivariable Cox regression analyses for the composite endpoint of all-cause mortality and readmission due to heart failure

From: Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction

  Composite endpoint All-cause mortality Readmission due to HF
HR (95% CI) p HR (95% CI) p HR (95% CI) p
PAPP-A
 Univariable 1.25 (1.09–1.42) 0.001 1.30 (1.12–1.51) 0.001 1.08 (0.85–1.38) 0.525
 Adjusted 1.13 (0.94–1.35) 0.185 1.10 (0.90–1.35) 0.340 0.94 (0.65–1.35) 0.729
Stanniocalcin-2
 Univariable 2.90 (1.81–4.64) < 0.001 2.52 (1.47–4.29) 0.001 5.37 (2.35–12.26) < 0.001
 Adjusted 2.06 (1.13–3.75) 0.018 2.23 (1.16–4.29) 0.017 3.42 (1.22–9.60) 0.020
IGFBP-4
 Univariable 3.29 (2.47–4.39) < 0.001 3.18 (2.30–4.39) < 0.001 2.69 (1.83–3.97) < 0.001
 Adjusted 1.73 (1.14–2.64) 0.010 1.44 (0.85–2.44) 0.170 0.82 (0.42–1.60) 0.562
Hs-TnT
 Univariable 1.48 (1.32–1.65) < 0.001 1.44 (1.27–1.63) < 0.001 1.64 (1.36–1.98) < 0.001
 Adjusted 1.07 (0.91–1.25) 0.424 1.04 (0.87–1.25) 0.665 1.00 (0.81–1.26) 0.959
NT-ProBNP
 Univariable 1.69 (1.54–1.84) < 0.001 1.66 (1.50–1.84) < 0.001 1.68 (1.43–1.97) < 0.001
 Adjusted 1.21 (1.07–1.37) 0.002 1.18 (1.02–1.36) 0.028 1.24 (0.92–1.68) 0.157
  1. All HRs (95% CIs) are reported per 1-SD increment of natural log-transformed plasma levels
  2. hs-TnT high-sensitivity troponin T, PAPP-A pregnancy-associated plasma protein-A, IGFBP-4 insulin-like growth factor binding protein-4