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Table 2 Clinical characteristics according to CKD273 risk threshold

From: Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria

Parameter

CKD273 > 0.343 (n = 69)

CKD273 < 0.343 (n = 86)

p value

Age (years)

62 (32–71)

61 (29–71)

0.173

Diabetes duration (years)

13 (1–35)

12.5 (1–36)

0.455

Gender (m/f)

59/10

59/27

*0.014

Smokers (year/n)

24/45

18/68

0.054

BMI (kg/m2)

31 (23–56)

32 (22–48)

0.324

SBP (mmHg)

130 ± 17

129 ± 16

0.725

DBP (mmHg)

74 ± 11

75 ± 12

0.574

HbA1c [%] (mmol/mol)

[7.5] 58 (42–110)

[7.6] 60 (39–123)

0.267

Cholesterol (mmol/L)

3.9 (2.3–6.7)

3.8 (2–6.6)

0.893

HDL (mmol/L)

1.1 (0.4–2.2)

1.1 (0.7–3.1)

0.066

LDL (mmol/L)

1.8 (0.5–4.4)

1.7 (0.4–4.2)

0.342

Creat (µmol/L)

80 ± 18

75 ± 17

*0.049

eGFR (mL/min/1.73 m2)

86 ± 18

90 ± 15

0.143

UAER (mg/24 h)

148 [70;385]

55 [29;99]

*< 0.001

CKD273

0.546 (0.369–1.231)

0.041 (− 1.078 to 0.347)

*< 0.001

CAD238

− 0.463 ± 0.202

− 0.586 ± 0.281

*0.002

NT-proBNP (ng/L)

52 (5–550)

42 (5–576)

0.615

CAC score

676 ± 961

363 ± 547

0.018

  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycated haemoglobin, HDL high density lipoprotein, LDL low density lipoprotein, eGFR estimated glomerular filtration rate, UAER urine albumin excretion rate, NT-proBNP N-terminal pro-brain natriuretic peptide, CAC coronary artery calcium. Data are mean ± SD or median (range). UAER expressed as geometric mean and interquartile range. eGFR determined by CKD-EPI formula. p < 0.05 and * denote statistical significance. Comparisons between groups are by 2-sample t test or appropriately transformed data where necessary. Numerical CKD273 cut-off for diagnosis of DN is 0.343