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Table 2 Clinical characteristics according to CKD273 risk threshold

From: Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria

Parameter CKD273 > 0.343 (n = 69) CKD273 < 0.343 (n = 86) p value
Age (years) 62 (32–71) 61 (29–71) 0.173
Diabetes duration (years) 13 (1–35) 12.5 (1–36) 0.455
Gender (m/f) 59/10 59/27 *0.014
Smokers (year/n) 24/45 18/68 0.054
BMI (kg/m2) 31 (23–56) 32 (22–48) 0.324
SBP (mmHg) 130 ± 17 129 ± 16 0.725
DBP (mmHg) 74 ± 11 75 ± 12 0.574
HbA1c [%] (mmol/mol) [7.5] 58 (42–110) [7.6] 60 (39–123) 0.267
Cholesterol (mmol/L) 3.9 (2.3–6.7) 3.8 (2–6.6) 0.893
HDL (mmol/L) 1.1 (0.4–2.2) 1.1 (0.7–3.1) 0.066
LDL (mmol/L) 1.8 (0.5–4.4) 1.7 (0.4–4.2) 0.342
Creat (µmol/L) 80 ± 18 75 ± 17 *0.049
eGFR (mL/min/1.73 m2) 86 ± 18 90 ± 15 0.143
UAER (mg/24 h) 148 [70;385] 55 [29;99] *< 0.001
CKD273 0.546 (0.369–1.231) 0.041 (− 1.078 to 0.347) *< 0.001
CAD238 − 0.463 ± 0.202 − 0.586 ± 0.281 *0.002
NT-proBNP (ng/L) 52 (5–550) 42 (5–576) 0.615
CAC score 676 ± 961 363 ± 547 0.018
  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycated haemoglobin, HDL high density lipoprotein, LDL low density lipoprotein, eGFR estimated glomerular filtration rate, UAER urine albumin excretion rate, NT-proBNP N-terminal pro-brain natriuretic peptide, CAC coronary artery calcium. Data are mean ± SD or median (range). UAER expressed as geometric mean and interquartile range. eGFR determined by CKD-EPI formula. p < 0.05 and * denote statistical significance. Comparisons between groups are by 2-sample t test or appropriately transformed data where necessary. Numerical CKD273 cut-off for diagnosis of DN is 0.343