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Table 4 Subgroup analysis of the associations between change in fasting glucose and the risk of all-cause morality

From: The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study

Fasting glucose level at baseline (mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL)
Fasting glucose level after 2-year (mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL) DFG (≥ 126.0 mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL) DFG (≥ 126.0 mg/dL)
Age < 65 years
 Subtotal (N) 136,764 32,057 3188 28,272 19,977 3615
 Number of cases (n) 2,5864 746 146 700 541 137
 HR (95% CI) 1 1.07 (0.98–1.16) 1.72 (1.46–2.04) 0.94 (0.84–1.05) 1 1.23 (1.02–1.48)
Age ≥ 65 years
 Subtotal (N) 19,957 5765 829 5335 3879 849
 Number of cases (n) 2661 855 168 816 579 152
 HR (95% CI) 1 1.11 (1.03–1.20) 1.46 (1.25–1.71) 1.01 (0.91–1.13) 1 1.17 (0.98–1.40)
Men
 Subtotal (N) 83,348 23,763 2790 20,418 16,354 3240
 Number of cases (n) 3726 1213 252 1123 842 214
 HR (95% CI) 1 1.07 (1.01–1.14) 1.60 (1.40–1.82) 1.01 (0.92–1.11) 1 1.12 (0.96–1.30)
Women
 Subtotal (N) 73,373 14,059 1227 13,189 7502 1224
 Number of cases (n) 1499 388 62 393 278 75
 HR (95% CI) 1 1.09 (0.97–1.22) 1.36 (1.06–1.76) 0.87 (0.75–1.02) 1 1.29 (0.99–1.67)
BMI < 25.0 kg/m2
 Subtotal (N) 111,438 24,195 2411 22,436 14,195 2368
 Number of cases (n) 3983 1188 224 1160 777 193
 HR (95% CI) 1 1.11 (1.04–1.18) 1.50 (1.31–1.72) 1.00 (0.92–1.10) 1 1.21 (1.03–1.42)
BMI ≥ 25.0 kg/m2
 Subtotal (N) 45,255 13,615 1605 11,157 9651 2095
 Number of cases (n) 1241 412 90 355 343 96
 HR (95% CI) 1 1.00 (0.89–1.12) 1.65 (1.33–2.04) 0.92 (0.79–1.07) 1 1.08 (0.86–1.36)
  1. Hazard ratio analyzed by Cox proportional hazards regression analysis adjusted for age, sex, socioeconomic status, physical activity, smoking status, alcohol consumption, body mass index, blood pressure, total cholesterol, Charlson comorbidity index, and baseline fasting glucose level
  2. n number, HR hazard ratio, CI confidential interval, NFG normal fasting glucose (< 100.0 mg/dL), IFG impaired fasting glucose (100.0–125.9 mg/dL), DFG, diabetic fasting glucose (≥ 126.0 mg/dL)