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Table 3 Subgroup analysis of the associations between change in fasting glucose and the risk of stroke

From: The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study

Fasting glucose level at baseline (mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL)
Fasting glucose level after 2-year (mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL) DFG (≥ 126.0 mg/dL) NFG (< 100.0 mg/dL) IFG (100.0–125.9 mg/dL) DFG (≥ 126.0 mg/dL)
Age < 65 years
 Subtotal (N) 136,764 32,057 3188 28,272 19,977 3615
 Number of cases (n) 2687 747 95 703 518 107
 HR (95% CI) 1 1.06 (0.97–1.15) 1.19 (0.97–1.47) 1.03 (0.91–1.15) 1 1.01 (0.82–1.24)
Age ≥ 65 years
 Subtotal (N) 19,957 5765 829 5335 3879 849
 Number of cases (n) 1726 527 87 479 366 102
 HR (95% CI) 1 1.04 (0.95–1.15) 1.20 (0.97–1.50) 0.99 (0.87–1.14) 1 1.22 (0.98–1.53)
Men
 Subtotal (N) 83,348 23,763 2790 20,418 16,354 3240
 Number of cases (n) 2416 790 117 717 599 149
 HR (95% CI) 1 1.05 (0.97–1.14) 1.16 (0.96–1.40) 1.00 (0.90–1.12) 1 1.08 (0.90–1.30)
Women
 Subtotal (N) 73,373 14,059 1227 13,189 7502 1224
 Number of cases (n) 1997 484 65 465 285 60
 HR (95% CI) 1 1.03 (0.94–1.14) 1.25 (0.97–1.60) 1.03 (0.89–1.20) 1 1.08 (0.82–1.43)
BMI < 25.0 kg/m2
 Subtotal (N) 111,438 24,195 2411 22,436 14,195 2368
 Number of cases (n) 3030 819 113 756 534 114
 HR (95% CI) 1 1.06 (0.98–1.15) 1.18 (0.97–1.42) 0.97 (0.87–1.09) 1 1.07 (0.88–1.32)
BMI ≥ 25.0 kg/m2
 Subtotal (N) 45,255 13,615 1605 11,157 9651 2095
 Number of cases (n) 1383 455 69 426 349 95
 HR (95% CI) 1 1.00 (0.90–1.12) 1.20 (0.94–1.53) 1.09 (0.94–1.26) 1 1.12 (0.89–1.41)
  1. Hazard ratio analyzed by Cox proportional hazards regression analysis adjusted for age, sex, socioeconomic status, physical activity, smoking status, alcohol consumption, body mass index, blood pressure, total cholesterol, Charlson comorbidity index, and baseline fasting glucose level
  2. n number, HR hazard ratio, CI confidential interval, NFG normal fasting glucose (< 100.0 mg/dL), IFG impaired fasting glucose (100.0–125.9 mg/dL), DFG diabetic fasting glucose (≥ 126.0 mg/dL)