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Table 2 The HR for each individual bone marker and the effect on CVD

From: Bone markers and cardiovascular risk in type 2 diabetes patients

  Q1 Q2 Q3 Q4 Ptrend Continuous
Osteocalcin
 (Median, ng/ml) 14.22 19.68 25.45 34.75   
 Events 33/68 41/80 29/67 31/73   Per 5 ng/ml
 Model 1 Ref 0.91 (0.58–1.42) 0.74 (0.44–1.25) 0.83 (0.51–1.35) 0.40 1.01 (0.98–1.02)
 Model 2 Ref 0.90 (0.59–1.47) 0.94 (0.55–1.60) 1.10 (0.67–1.81) 0.64 1.01 (0.99–1.02)
 Model 3 Ref 0.83 (0.51–1.36) 0.92 (0.53–1.59) 1.17 (0.70–1.93) 0.43 1.01 (1.00–1.03)
Osteopontin
 (Median, ng/ml) 8.84 11.66 13.78 18.72   
 Events 23/63 31/70 36/74 44/81   Per 5 ng/ml
 Model 1 Ref 1.18 (0.70–1.97) 1.51 (0.89–2.56) 1.70 (1.03–2.78) 0.02 1.08 (0.97–1.20)
 Model 2 Ref 1.34 (0.78–2.33) 1.79 (1.06–3.02) 1.76 (1.08–2.88) 0.02 1.08 (0.98–1.20)
 Model 3 Ref 1.36 (0.76–2.44) 1.66 (0.95–2.89) 2.00 (1.20–3.35) < 0.01 1.11 (1.01–1.21)
Osteonectin
 (Median, ng/ml) 71.78 103.40 127.9 195.6   
 Events 29/70 23/65 41/75 41/78   Per 10 ng/ml
 Model 1 Ref 0.83 (0.48–1.44) 1.63 (1.02–2.60) 1.39 (0.85–2.20) 0.08 1.02 (1.00–1.03)
 Model 2 Ref 0.77 (0.44–1.32) 1.32 (0.82–2.14) 1.16 (0.72–1.88) 0.30 1.02 (1.00–1.04)
 Model 3 Ref 0.74 (0.43–1.27) 1.25 (0.76–2.05) 1.16 (0.72–1.88) 0.30 1.02 (1.00–1.04)
Osteoprotegerin
 (Median, ng/ml) 134.4 168.3 199.0 256.6   
 Events 30/69 28/69 32/73 44/77   Per 10 ng/ml
 Model 1 Ref 0.88 (0.53–1.46) 0.91 (0.56–1.46) 1.51 (0.91–2.52) 0.07 1.03 (1.00–1.06)
 Model 2 Ref 0.82 (0.50–1.36) 0.87 (0.53–1.44) 1.13 (0.65–1.98) 0.46 1.01 (0.98–1.04)
 Model 3 Ref 0.88 (0.52–1.47) 0.84 (0.49–1.45) 1.23 (0.69–2.19) 0.35 1.01 (0.98–1.05)
Alkaline phosphatase
 (Median, ng/ml) 42.0 51.39 59.7 74.4   
 Events 35/68 31/73 25/68 43/79   Per 10 ng/ml
 Model 1 Ref 0.79 (0.49–1.29) 0.67 (0.40–1.14) 1.13 (0.71–1.79) 0.52 1.07 (0.94–1.21)
 Model 2 Ref 0.74 (0.45–1.22) 0.67 (0.39–1.16) 1.03 (0.61–1.73) 0.64 1.02 (0.89–1.18)
 Model 3 Ref 0.79 (0.47–1.35) 0.68 (0.39–1.17) 1.05 (0.60–1.85) 0.66 1.03 (0.89–1.19)
Sclerostin
 (Median, ng/ml) 40.65 53.6 67.8 93.6   
 Events 29/65 35/73 42/79 28/71   Per 10 ng/ml
 Model 1 Ref 1.07 (0.65–1.78) 1.18 (0.74–1.89) 0.83 (0.49–1.40) 0.42 0.99 (0.97–1.02)
 Model 2 Ref 1.05 (0.64–1.73) 1.04 (0.64–1.67) 0.76 (0.44–1.32) 0.27 0.99 (0.96–1.02)
 Model 3 Ref 1.15 (0.68–1.93) 1.07 (0.65–1.75) 0.75 (0.41–1.36) 0.24 0.99 (0.96–1.02)
  1. Model 1: Adjusted of sex (age is the underlying time scale)
  2. Model 2: Additionally adjusted for BMI, smoking status, prevalent CVD, hs-CRP, total cholesterol and HDL cholesterol
  3. Model 3: Additionally adjusted for age at onset of diabetes, HbA1c levels and eGFR