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Table 4 Multiple regression analysis of BRS

From: Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report

Dependent variables

Model 1

Model 2

β

p

β

p

(a)

 CGM-SD (mg/dL)

− 0.218

0.051

− 0.336

0.004

 Age (years)

− 0.435

0.000

–

–

 Sex (male/female)

− 0.029

0.731

− 0.061

0.506

 Hypertension

− 0.073

0.418

− 0.087

0.369

 Dyslipidemia

− 0.183

0.038

− 0.166

0.080

 Heart rate (beats/min)

− 0.259

0.004

− 0.244

0.012

 eGFR (mL/min/1.73 m2)

0.035

0.714

0.138

0.160

 CAVI

–

–

− 0.216

0.028

 CGM-mean glucose (mg/dL)

0.119

0.240

0.199

0.066

(b)

 CGM-CV (mg/dL)

− 0.206

0.032

− 0.304

0.002

 Age (years)

− 0.427

0.000

–

–

 Sex (male/female)

− 0.031

0.711

− 0.063

0.492

 Hypertension

− 0.071

0.428

− 0.084

0.385

 Dyslipidemia

− 0.184

0.036

− 0.166

0.077

 Heart rate (beats/min)

− 0.257

0.004

− 0.243

0.012

 eGFR (mL/min/1.73 m2)

0.042

0.657

0.149

0.125

 CAVI

–

–

− 0.207

0.035

 CGM-mean glucose (mg/dL)

0.012

0.889

0.034

0.721

(c)

 MAGE (mg/dL)

− 0.227

0.036

− 0.346

0.002

 Age (years)

− 0.414

0.000

–

–

 Sex (male/female)

− 0.020

0.809

− 0.044

0.630

 Hypertension

− 0.088

0.328

− 0.110

0.256

 Dyslipidemia

− 0.165

0.055

− 0.139

0.131

 Heart rate (beats/min)

− 0.274

0.002

− 0.269

0.005

 eGFR (mL/min/1.73 m2)

0.035

0.712

0.135

0.166

 CAVI

–

–

− 0.179

0.074

 CGM-mean glucose (mg/dL)

0.119

0.231

0.192

0.069

  1. The dependent variable was BRS, and the independent variables were Model 1 and Model 2. Model 1: adjustment for GV, age, sex, hypertension, dyslipidemia, heart rate, eGFR, and CGM-mean glucose; Model 2: adjustment for GV, sex, hypertension, dyslipidemia, heart rate, eGFR, CAVI, and CGM-mean glucose; GV was (a) CGM-SD, (b) CGM-CV, and (c) MAGE. Model 1 (a) R-squared 0.414, adjusted R-squared 0.359; (b) R-squared 0.420, adjusted R-squared 0.365; (c) R-squared 0.418, adjusted R-squared 0.364; Model 2 (a) R-squared 0.321, adjusted R-squared 0.257, (b) R-squared 0.328, adjusted R-squared 0.264, (c) R-squared 0.329, adjusted R-squared 0.266
  2. BRS baroreflex sensitivity, CGM continuous glucose monitoring, SD standard deviation, CV coefficient of variance, MAGE mean amplitude of glycemic excursions, eGFR estimated glomerular filtration rate, CAVI cardio-ankle vascular index