Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Table 4 Crude and adjusted Hazard ratios in PCOS Denmark (N = 18,112) and controls (N = 52,769) and development of CVD

	Crude HR (95% CI)	Adjusted HR HR (95% CI)	Adjusted HR HR (95% CI)	Adjusted HR HR (95% CI)	Adjusted HR HR (95% CI)	Adjusted HR HR (95% CI)	Adjusted HR HR (95% CI)
Outcome: CVD
PCOS (yes/no)	1.7 (1.7; 1.8) P < 0.001	1.6 (1.5; 1.7) P < 0.001	1.7 (1.6; 1.8) P < 0.001	1.7 (1.6; 1.8) P < 0.001	1.7 (1.6; 1.7) P < 0.001	1.7 (1.6; 1.8) P < 0.001	1.6 (1.5; 1.6) P < 0.001
Predictors
Obesity		2.7 (2.4; 3.1) P < 0.001					2.4 (2.1; 2.7) P < 0.001
Diabetes (yes/no)			4.9 (4.1; 5.9) P < 0.001				4.4 (3.6; 5.3) P < 0.001
Infertility (yes/no)				1.2 (1.1; 1.3) P = 0.001			1.0 (0.9; 1.1) P = 0.802
Comorbidity					1.6 (1.4; 1.8) P < 0.001
OCP (yes/no)						1.1 (1.1; 1.2) P < 0.001	1.1 (1.1; 1.2) P < 0.001
Outcome: CVD (HT and DL excluded)
PCOS (yes/no)	1.4 (1.3; 1.5) P < 0.001	1.3 (1.2; 1.4) P < 0.001	1.4 (1.3; 1.5) P < 0.001	1.4 (1.3; 1.5) P < 0.001	1.4 (1.3; 1.8) P < 0.001	1.4 (1.3; 1.5) P < 0.001	1.3 (1.2; 1.4) P < 0.001
Predictors
Obesity		2.4 (1.9; 3.1) P < 0.001					2.1 (1.7; 2.7) P < 0.001
Diabetes (yes/no)			2.9 (2.2; 3.8) P < 0.001				2.5 (1.9; 3.3) P < 0.001
Infertility (yes/no)				1.3 (1.1; 1.5) P = 0.001			1.2 (1.0; 1.4) P = 0.019
Comorbidity					1.8 (1.5; 2.1) P < 0.001
OCP (yes/no)						1.0 (0.9; 1.1) P = 0.661	1.0 (0.9; 1.1) P = 0.687

Predictors for development of CVD in PCOS Denmark and controls
Comorbidity was defined as a Charlson index ≥ 1
Hazard ratios are presented for crude models and models corrected for obesity, diabetes, infertility, and use of OCP at the index date
Diabetes defined as type 1 or type 2 diabetes or gestational diabetes according to ICD10s (E10, E11, E13, E14, O24)

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