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Table 3 Characteristics according to development of CVD in PCOS Denmark and controls

From: Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

  Development of CVD in PCOS Development of CVD in controls PCOS vs. controls P A vs. B P A vs. C
Total Yes A No B Total Yes C No D
Development of CVD 17,995 3970 14,025 52,329 7344 44,985    
Age at diagnosis (years) Median (Q1, Q3) 29 (23–35) 35 (28–42) 28 (22–33) 29 (23–35) 36 (30–43) 28 (23–33) 0.009 < 0.001 < 0.001
  N (%) N (%) N (%) N (%) N (%) N (%)    
Age < 50 years 17,331 (96) 3591 (90) 13,740 (98) 50,718 (97) 6496 (88) 44,222 (98) < 0.001 < 0.001 0.001
Baseline characteristics
 Obesity 2005 (11) 444 (11) 1561 (11) 648 (1) 121 (2) 527 (1) < 0.001 0.924 < 0.001
 Diabetes 448 (3) 198 (5) 250 (2) 367 (1) 163 (2) 204 (1) < 0.001 < 0.001 < 0.001
 Infertility 4158 (23) 751 (19) 3407 (24) 2007 (4) 259 (4) 1748 (4) < 0.001 < 0.001 < 0.001
 Comorbidity 796 (4) 215 (5) 581 (4) 1646 (3) 253 (3) 1393 (3) < 0.001 0.001 < 0.001
 Oral contraceptives 10,432 (58) 1752 (44) 8680 (62) 16,005 (31) 1652 (23) 14,353 (32) < 0.001 < 0.001 < 0.001
Development of CVD (HT and DL excluded) 17,995 1290 16,705 52,329 2678 49,651    
Age at diagnosis (years) Median (Q1, Q3) 29 (23–35) 36 (29–44) 29 (23–35) 29 (23–35) 38 (31–46) 28 (23–34) 0.009 < 0.001 < 0.001
  N (%) N (%) N (%) N (%) N (%) N (%)    
Age < 50 years 17,331 (96) 1098 (85) 16,233 (97) 50,718 (97) 2235 (83) 48,4834 (98) < 0.001 < 0.001 0.182
Baseline characteristics
 Obesity 2005 (11) 128 (10) 1877 (11) 648 (1) 39 (1) 609 (1) < 0.001 0.149 < 0.001
 Diabetes 448 (3) 60 (5) 388 (2) 367 (1) 57 (2) 310 (1) < 0.001 < 0.001 < 0.001
 Infertility 4158 (23) 217 (17) 3941 (24) 2007 (4) 95 (4) 1912 (4) < 0.001 < 0.001 < 0.001
 Comorbidity 796 (4) 98 (8) 698 (4) 1646 (3) 105 (4) 1541 (3) < 0.001 < 0.001 < 0.001
 Oral contraceptives 10,432 (58) 497 (39) 9935 (60) 16,005 (31) 513 (19) 15,492 (31) < 0.001 < 0.001 < 0.001
  1. Comorbidity was defined as a Charlson index ≥ 1
  2. ICD 10 codes OCP (oral contraceptives): G03AA, G03AB, G03HB01
  3. Hypertension (HT) defined as ICD10 codes I10–13 OR prescription of C02, C07–09
  4. Dyslipidemia (DL) defined as (ICD 10 code) E78 OR prescription of C10
  5. Two or more medicine withdrawals should occur within the same ATC group 3 months or later after the index date)
  6. Diabetes defined as type 1 or type 2 diabetes or gestational diabetes according to ICD10: E10, E11, E13, E14, O24
  7. P values obtained with Chi squared test for categorical variables and non-parametric test on the equality of medians for continuous variables