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Table 2 Baseline clinical and biochemical characteristics according to subsequent development of CVD in PCOS OUH

From: Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

  Development of CVD P#
Yes N = 264 No N = 895
Baseline characteristics N (%) Median (Q1–Q3) N (%) Median (Q1–Q3)
Age (years) 230 (100) 35 (28–39) 935 (100) 27 (21–33) < 0.001
BMI (kg/m2) 245 (93) 30.2 (25.1–35,2) 831 (93) 26.1 (22.6–31.1) < 0.001
Waist (cm) 134 (51) 100 (84–110) 587 (66) 87 (77–100) < 0.001
Systolic BP (mmHg) 148 (56) 130 (120–140) 624 (70) 123 (114–131) 0.002
Diastolic BP (mmHg) 148 (56) 85 (78–92) 650 (70) 80 (70–86) < 0.001
LDL cholesterol (mmol/L) 184 (70) 3.2 (2.6–3.9) 663 (74) 2.6 (2.1–3.1) 0.275
HDL cholesterol (mmol/L) 186 (70) 1.3 (1.1–1.6) 663 (74) 1.4 (1.1–1.6) < 0.001
Cholesterol (mmol/L) 186 (70) 5.2 (4.5–5.9) 674 (75) 4.5 (4.0–5.1) < 0.001
Triglycerides (mmol/L) 186 (70) 1.3 (0.9–1.9) 662 (74) 1.0 (0.7–1.3) 0.026
Prolactin (µg/L) 223 (85) 6 (5–9) 731 (82) 7 (5–10) 0.010
HbA1c (mmol/mol) 108 (41) 37 (33–42) 463 (52) 33 (31–37) 0.298
Fasting blood glucose (mmol/L) 150 (57) 4.7 (4.2–5.0) 384 (43) 4.6 (4.3–5.0) 0.012
2 h blood glucose (mmol/L) 149 (56) 6.4 (5.3–7.6) 373 (42) 6.0 (5.2–6.9) 0.001
Fasting insulin (pmol/L) 157 (60) 60 (40–114) 410 (46) 53 (36–82) 0.002
HOMA-ir (pmol mmol/L2) 152 (58) 14.8 (9.1–25.9) 388 (43) 11.3 (7.6–17.1) 0.330
Total testosterone (nmol/L) 170 (64) 1.7 (1.2–2.3) 655 (73) 1.8 (1.3–2.5) 0.708
SHBG (nmol/L) 244 (92) 45 (30–64) 829 (93) 44 (31–67) 0.367
Free testosterone (nmol/L) 167 (63) 0.032 (0.021–0.049) 644 (72) 0.033 (0.021–0.050) 0.012
  P¤
BMI ≥ 25 kg/m2 186 (76)   469 (56)   < 0.001
BMI < 25 kg/m2 59 (24)   362 (44)   
Waist ≥ 88 cm 94 (71)   277 (47)   < 0.001
Waist < 88 cm 40 (30)   310 (53)   
Systolic BP ≥ 130 mmHg 84 (57)   205 (33)   < 0.001
Systolic BP < 130 mmHg 64 (43)   420 (67)   
Diastolic BP ≥ 85 mmHg 77 (52)   186 (30)   < 0.001
Diastolic BP < 85 mmHg 71 (48)   438 (70)   
Triglycerides ≥ 1.7 mmol/L 63 (34)   93 (15)   < 0.001
Triglycerides < 1.7 mmol/L 123 (66)   569 (86)   
  1. Data presented as median (Q1–Q3)
  2. BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG Sex hormone-binding globulin
  3. P#: non-parametric test on the equality of medians
  4. P¤: Chi squared test