Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Table 1 Event rates of CVD in PCOS OUH, PCOS Denmark and controls

	PCOS OUH (N = 1159)		PCOS Denmark (N = 17,995)		Controls (N = 52,329)		P^a	P^b
	N (%)	IR	N (%)	IR	N (%)	IR	P^a	P^b
CVD events	264 (23)	22.6	3970 (22)	22.0	7344 (14)	13.2	< 0.001	0.54
CVD (HT and DL excluded)	71 (6)	5.4	1290 (7)	6.4	2678 (5)	4.5	< 0.001	0.16
ICD10 CVD, total	121 (10)	9.5	1727 (10)	8.7	3089 (6)	5.2	< 0.001	0.31
E 78 (dyslipidemia)	33 (3)	2.5	431 (2)	2.1	653 (1)	1.1	< 0.001	0.30
G45–46, I63–66 (TCI, stroke)	16 (1)	1.2	206 (1)	1.0	524 (1)	0.9	0.102	0.44
I10–13 (hypertension)	77 (7)	5.9	1004 (6)	4.9	1484 (3)	2.5	< 0.001	0.10
I20–25 (CVD)	20 (2)	1.5	364 (2)	1.8	854 (2)	1.4	0.001	0.46
I26 (VTE lung)	4 (0.4)	0.3	97 (0.5)	0.5	151 (0.3)	0.2	< 0.001	0.35
I50 (incompensatio)	0	Na	47 (0.3)	0.2	200 (0.4)	0.3	0.018	0.07
I80–82 (VTE extremities)	17 (1)	1.3	216 (1)	1.0	451 (1)	0.7	< 0.001	0.39
Medical treatment	247 (21)	20.8	3643 (20)	20.0	6656 (13)	11.9	< 0.001	0.35
Antithrombotics (B01)	50 (4)	3.8	940 (5)	4.6	1887 (4)	3.2	< 0.001	0.15
Antihypertensive (C02, C07–09)	189 (16)	15.4	2744 (15)	14.5	5087 (10)	8.9	< 0.001	0.30
Antilipids (C10)	121 (10)	9.4	1601 (9)	8.1	2833 (5)	4.8	< 0.001	0.06

IR: incidence rate. Presented per 1000 PY (person years)
VTE: venous thromboembolism
HT: hypertension defined as ICD10 codes I10–13 OR prescription of C02, C07–09 (two or more medicine withdrawals within the same ATC group 3 months or later after the index date)
DL: dyslipidemia defined as (ICD 10 code) E78 OR prescription of C10 (two or more medicine withdrawals within the same ATC group 3 months or later after the index date)
P^a: Chi square test between PCOS Denmark and controls
P^b: Chi square test between PCOS OUH and controls

ISSN: 1475-2840